{"559901":{"#nid":"559901","#data":{"type":"event","title":"PhD Proposal by Akia Parks","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAkia Parks\u003C\/strong\u003E \u003Cbr \/\u003E PhD Proposal Presentation\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EDate:\u003C\/strong\u003E Tuesday August 16\u003Csup\u003Eth\u003C\/sup\u003E, 2016\u003Cbr \/\u003E \u003Cstrong\u003ETime:\u003C\/strong\u003E 12:00 pm\u003Cbr \/\u003E \u003Cstrong\u003ELocation:\u003C\/strong\u003E Whitaker 1103\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECommittee Members: \u003C\/strong\u003E\u003Cbr \/\u003E Manu O. Platt, PhD (Advisor) \u003Cbr \/\u003E Johnna S. Temenoff, PhD\u003Cbr \/\u003E Edward A. Botchwey, PhD\u003Cbr \/\u003E Rudolph L. Gleason, PhD\u003Cbr \/\u003E Claude D. Jarrett, MD\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ETemporal Cathepsin and Matrix Metalloproteinase Activity in Tendon Extracellular Matrix\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EEarly stage tendinopathy, or tendon overuse, is one of the most common musculoskeletal disorders affecting athletes, laborers, and aging adults. If left untreated, overuse injury can progress to partial or full-thickness tears that require surgical intervention. In order to development preventative treatment strategies, it is important to understand what initiates tendon damage. The multifactorial etiology of tendon overuse includes imbalances in proteases and their endogenous inhibitors that lead to the degradation of extracellular matrix (ECM) components. Matrix metalloproteinases (MMPs) and, more recently, cathepsins have been implicated in tendon pathogenesis. However, in the context of the greater proteolytic network affecting cathepsins, MMPs, and their inhibitors, it is not known how these two families work cooperatively to effectively degrade tendon ECM. The objective of this project is to investigate this proteolytic contribution to tendon damage. It is hypothesized that cathepsins, especially cathepsin K, and MMPs play a temporal role in ECM degeneration. The proposed study aims to use a rat model of rotator cuff tendinopathy to determine the temporal roles of proteases in supraspinatus tendon overuse injury. This study will also use decellularized Achilles tendons from wild type and cathepsin K deficient mice to determine the sequential actions of cathepsins and MMPs on tendon collagenolysis. Together, this work will determine the biochemical roles of cathepsins and MMPs on tendon damage and elucidate mechanisms of protease and inhibitor regulation. Understanding how the proteolytic network contributes to tendon degradation will better inform clinical treatment strategies to prevent progression to tendon failure.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E \u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Temporal Cathepsin and Matrix Metalloproteinase Activity in Tendon Extracellular Matrix"}],"uid":"27707","created_gmt":"2016-08-08 07:59:16","changed_gmt":"2016-10-08 02:18:36","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-08-16T13:00:00-04:00","event_time_end":"2016-08-16T15:00:00-04:00","event_time_end_last":"2016-08-16T15:00:00-04:00","gmt_time_start":"2016-08-16 17:00:00","gmt_time_end":"2016-08-16 19:00:00","gmt_time_end_last":"2016-08-16 19:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}