{"532001":{"#nid":"532001","#data":{"type":"event","title":"Integrated Cancer Research Center Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022The Biology of Radiotherapy-Associated Side Effects in Breast Cancer Patients\u0022\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EMylin A. Torres, M.D.\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAssociate Professor\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EDepartment of Radiation Oncology\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EDirector of the Glenn Family Breast Center\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EWinship\u0027s Glenn Family Breast Center\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EEmory University School of Medicine\u003C\/strong\u003E\u003C\/p\u003E\u003Cp class=\u0022p1\u0022\u003ECurrently, there are 3 million survivors of breast cancer, and this growing population has recognized a need for strategies aimed at identifying patients at risk for radiation (RT) side effects and for preventing long term sequelae of treatment.\u0026nbsp; Acute RT dermatitis is one of the most common side effects of RT and may be a cause of poor compliance with treatment.\u0026nbsp; During RT, approximately 70% of patients develop significant cutaneous toxicity including moist skin desquamation, erythema, and hyperpigmentiation. Moreover, up to 40% of women will develop long term breast side effects including skin thickening, telangiectasias, fibrosis, induration, breast contracture, and pain.\u0026nbsp; Studies have shown that predictors of RT-induced skin toxicity include large breast size and prior chemotherapy treatment as well as factors related to RT treatment itself (e.g. radiation dose per fraction and total dose delivered).\u0026nbsp; Nevertheless, the underlying biological mechanisms that underlie RT-induced skin changes remain unclear, and clinicians are still unable to reliably identify patients who are at risk for significant RT-induced breast disfigurement, pain, and poor quality of life.\u0026nbsp; The recent development of the 21 gene recurrence score which assesses an individual breast cancer patient\u2019s risk of distant recurrence has revolutionized the ability of clinicians to personalize treatment.\u0026nbsp; However, no such assay exists for predicting an individual patient\u2019s risk of significant toxicities from cancer therapies.\u0026nbsp; Indeed, a patient\u2019s unique biological response to RT may significantly impact the development of RT-induced breast toxicities and ultimately breast disfigurement and pain.\u0026nbsp; Using ultrasound tissue characterization, we have obtained objective measures of skin changes in two prospectively studied cohorts of breast cancer patients before, during, and after RT.\u0026nbsp; We have identified patient and treatment characteristics associated with short and long term RT skin toxicity.\u0026nbsp; We are currently evaluating biological predictors of RT-skin toxicity. This information will allow clinicians and patients to make important and tailored decisions regarding clinical management of breast cancer.\u0026nbsp; The data will also serve as foundation for the development of proactive preventative strategies early in cancer treatment to prevent breast disfigurement and pain.\u0026nbsp; Of direct clinical relevance, early stage breast cancer patients who are reliably identified as being at significant risk for RT-induced skin changes, may elect for mastectomy (as opposed to breast conserving surgery), which precludes the need for treatment with RT. \u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022p2\u0022\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"\u0022The Biology of Radiotherapy-Associated Side Effects in Breast Cancer Patients\u0022 - Mylin A. Torres, M.D. - Emory University School of Medicine"}],"uid":"27349","created_gmt":"2016-05-03 11:29:55","changed_gmt":"2017-04-13 21:15:55","author":"Floyd Wood","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-05-17T17:00:00-04:00","event_time_end":"2016-05-17T18:00:00-04:00","event_time_end_last":"2016-05-17T18:00:00-04:00","gmt_time_start":"2016-05-17 21:00:00","gmt_time_end":"2016-05-17 22:00:00","gmt_time_end_last":"2016-05-17 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"361991":{"id":"361991","type":"image","title":"Integrated Cancer Research Center","body":null,"created":"1449245782","gmt_created":"2015-12-04 16:16:22","changed":"1475895098","gmt_changed":"2016-10-08 02:51:38","alt":"Integrated Cancer Research Center","file":{"fid":"201581","name":"icrc_logo_image_2014-square.jpg","image_path":"\/sites\/default\/files\/images\/icrc_logo_image_2014-square_0.jpg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/images\/icrc_logo_image_2014-square_0.jpg","mime":"image\/jpeg","size":3173213,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/icrc_logo_image_2014-square_0.jpg?itok=i_uQpBWu"}}},"media_ids":["361991"],"related_links":[{"url":"http:\/\/radiationoncology.emory.edu\/people\/physicians\/torres-mylin.html","title":"Torres profile"},{"url":"http:\/\/petitinstitute.gatech.edu\/integrated-cancer-research-center-seminars","title":"ICRC Seminar Series Schedule"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"52061","name":"ICRC Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:john.mcdonald@biology.gatech.edu\u0022\u003EJohn McDonald\u003C\/a\u003E\u0026nbsp;- faculty host\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}