{"514701":{"#nid":"514701","#data":{"type":"event","title":"PhD Proposal by Brandon Johnson","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EBrandon Johnson\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EDate:\u003C\/strong\u003E\u0026nbsp;March 29th, 2016\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ETime:\u003C\/strong\u003E\u0026nbsp;4:00 PM\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ELocation:\u003C\/strong\u003E\u0026nbsp;Emory University, WMB 7115\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EThesis Committee:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003EYoung-Sup Yoon, MD, PhD (Thesis Advisor)\u003C\/p\u003E\u003Cp\u003EAndres Garcia, PhD\u003C\/p\u003E\u003Cp\u003EManu Platt, PhD\u003C\/p\u003E\u003Cp\u003EChangwon Park, PhD\u003C\/p\u003E\u003Cp\u003EHo-Wook Jun, PhD\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ETitle:\u0026nbsp;\u003C\/strong\u003EIncreased engraftment of highly angiogenic CD31+ cell subpopulations through encapsulation in a self-assembled nanomatrix gel\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EAbstract:\u0026nbsp;\u003C\/strong\u003EPeripheral artery disease (PAD) affects 5.9% of adults \u2265 40 years of age, remaining largely undetected and progresses into critical limb ischemia (CLI), a state of unrelenting rest pain and ulceration.\u0026nbsp; PreviousFor patients without revascularization options, amputation and mortality rates are roughly 40% and 20%, respectively.\u0026nbsp; Our laboratory is proposing to develop a novel cell therapy using highly angiogenic peripheral blood (PB) derived CD31\u003Csup\u003E+\u003C\/sup\u003E\u0026nbsp;cell subpopulations combined with self-assembled peptide amphiphile (PA) nanomatrix gels for treating CLI. Current cell therapies suffer from contamination with inhibitory cell types, undefined isolation methods, and\/or low engraftment and retention. To address this, we will analyze various PB-CD31\u003Csup\u003E+\u003C\/sup\u003E\u0026nbsp;cell subpopulations for their lineage composition and contribution to revascularization. Futhermore, Self-assembled nanomatrix gels have also been shown to provide a cyotprotective niche and increase cellular retention after transplantation.\u0026nbsp;\u003Cstrong\u003EWe hypothesize that the various regenerative effects of CD31+ cells can be discreetly delineated through CD14 expression and encapsulation in PA nanomatrix gels will increase retention and viabiliy of cells when injected into ischemic mouse hind limbs.\u0026nbsp;\u003C\/strong\u003EThe combination of highly angiogenic PB-CD31\u003Csup\u003E+\u003C\/sup\u003ECD14\u003Csup\u003E-\u003C\/sup\u003E\u0026nbsp;cells and PA nanomatrix hydrogels will provide a readily available, effective alternative therapy for CLI patients currently without treatment options. Information obtained in this study will likely impact the development of future cellular therapies for multiple cardiovascular diseases.\u003C\/p\u003E\u003Cp\u003E \u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Increased engraftment of highly angiogenic CD31+ cell subpopulations through encapsulation in a self-assembled nanomatrix gel"}],"uid":"27707","created_gmt":"2016-03-17 06:58:11","changed_gmt":"2016-10-08 02:17:06","author":"Tatianna Richardson","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-03-29T17:00:00-04:00","event_time_end":"2016-03-29T19:00:00-04:00","event_time_end_last":"2016-03-29T19:00:00-04:00","gmt_time_start":"2016-03-29 21:00:00","gmt_time_end":"2016-03-29 23:00:00","gmt_time_end_last":"2016-03-29 23:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}