{"491891":{"#nid":"491891","#data":{"type":"event","title":"PhD Proposal by Chad Glen","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003EAdvisors:\u0026nbsp;\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EMelissa Kemp, PhD\u003C\/strong\u003E\u0026nbsp;(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ETodd McDevitt, PhD\u0026nbsp;\u003C\/strong\u003E(Gladstone Institute of Cardiovascular Disease)\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EThesis Committee Members:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EMichael Levin, PhD\u0026nbsp;\u003C\/strong\u003E(Tufts University)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EKrishnendu Roy, PhD\u0026nbsp;\u003C\/strong\u003E(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EBrani Vidakovic, PhD\u003C\/strong\u003E\u0026nbsp;(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EEberhard Voit, PhD\u0026nbsp;\u003C\/strong\u003E(Georgia Institute of Technology)\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EComputational analysis of the intercellular network and its influence on driving spatial differentiation.\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;Gap junctions and their protein components, connexins, are associated with multiple cellular functions including metabolic coupling, tumor suppression, and modulation of cell signaling. This diversity of function results in gap junctions being crucial for regulating differentiation during development, while disruption of gap junctions is implicated in the pathology of numerous diseases. Specifically, inhibition of gap junctions in pluripotent stem cells has been reported to abrogate the maintenance of pluripotency, suggesting the gap junction intercellular network may provide a novel mechanism to promote differentiation within cell populations. However, the ability to interrogate intercellular communication networks in a spatiotemporal manner is currently limited. The\u003Cstrong\u003Eoverall objective\u003C\/strong\u003E\u0026nbsp;of this proposal is to determine spatiotemporal characteristics of the gap junction network that drive differentiation in embryonic stem cell colonies. Computational modeling provides a useful tool for analyzing the complex dynamics of various factors that affect intercellular communication, such as cell cycle state and connexin expression, and the resultant emergence of spatial patterns within the network. The\u0026nbsp;\u003Cstrong\u003Ecentral hypothesis\u0026nbsp;\u003C\/strong\u003Eis that spatial differentiation within pluripotent colonies is a function of dynamic intercellular communication. Convergent experimental and computational modeling techniques will be applied to assess how modulations to the intercellular network contributes to differentiation potential.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"Computational analysis of the intercellular network and its influence on driving spatial differentiation."}],"uid":"27690","created_gmt":"2016-01-27 17:27:10","changed_gmt":"2016-10-08 02:16:04","author":"Jacquelyn Strickland","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-02-08T10:00:00-05:00","event_time_end":"2016-02-08T12:00:00-05:00","event_time_end_last":"2016-02-08T12:00:00-05:00","gmt_time_start":"2016-02-08 15:00:00","gmt_time_end":"2016-02-08 17:00:00","gmt_time_end_last":"2016-02-08 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"221981","name":"Graduate Studies"}],"categories":[],"keywords":[{"id":"102851","name":"Phd proposal"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78771","name":"Public"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}