{"479691":{"#nid":"479691","#data":{"type":"event","title":"Ian Ehrenreich, USC","body":[{"value":"\u003Cp\u003ERoles of genetic variation, mutations, and environment in uncovering a cryptic phenotype\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EAbstract:\u003C\/p\u003E\u003Cp\u003ECryptic genetic variants that do not typically influence traits can interact with each other, the environment, and mutations to cause unexpected phenotypes. The genetic architectures and molecular mechanisms that underlie these interactions are not well understood. To help advance knowledge in this area, we comprehensively dissected the genetic basis of a cryptic yeast colony trait across multiple mutant backgrounds and environments in a yeast cross. Across our studies, we identified 12 specific genes and 6 uncharacterized loci that harbor cryptic variants, as well as 7 \u2018capacitor\u2019 genes that can reveal these cryptic variants when mutated. Additionally, we defined specific, complex combinations of epistatically interacting cryptic variants that can lead to the colony phenotype in particular mutant backgrounds or environments. Most of the identified capacitors and genes harboring cryptic variants act in the evolutionarily conserved and oncogenic Ras signaling cascade, and appear to influence the activities of antagonistic, Ras-regulated transcription factors. Thus, our results suggest that complicated genetic and environmental influences on gene regulatory networks play a key role in suppressing and uncovering cryptic phenotypes.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Ian Ehrenreich, USC"}],"uid":"27964","created_gmt":"2015-12-16 14:51:40","changed_gmt":"2017-04-13 21:17:23","author":"Jasmine Martin","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-03-31T16:00:00-04:00","event_time_end":"2016-03-31T16:00:00-04:00","event_time_end_last":"2016-03-31T16:00:00-04:00","gmt_time_start":"2016-03-31 20:00:00","gmt_time_end":"2016-03-31 20:00:00","gmt_time_end_last":"2016-03-31 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"1275","name":"School of Biological Sciences"}],"categories":[],"keywords":[{"id":"10645","name":"Greg Gibson"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EIf you have questions about logistics or would like to set up an appointment with the speaker, please contact the School of Biology\u0027s administrative office at \u003Ca href=\u0022mailto:bio-admin@biology.gatech.edu\u0022\u003Ebio-admin@biology.gatech.edu\u003C\/a\u003E.\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}