{"479591":{"#nid":"479591","#data":{"type":"event","title":"Nina Papavasiliou, Rockefeller University","body":[{"value":"\u003Cp\u003EGenerators of diversity and the host-pathogen interface\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EAbstract:\u003C\/p\u003E\u003Cp\u003EUnlike most static cells in the body, immune cells constantly migrate through environments that vary considerably both in steady state and during invasion by a pathogen. The unpredictability of these environments can be thought of as a selective force that through evolution has favored substantial population diversity in cells of the immune system.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EDiversification can happen at the level of DNA (through recombination or mutation) to produce, for example, novel receptors on B cells, than can better deal with pathogens. Not surprisingly, similar types of processes also occur in pathogens, for the purposes of evading a targeted immune response (and we will discuss the African trypanosome as an example of that).\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EBut diversification can also happen at the level of RNA. This type of transcriptomic diversity is generated by robust and targeted RNA editing (an \u0022active\u0022 form of mutation, which depends on concurrent expression of the editing deaminases of the APOBEC or ADAR families, and which unlike DNA mutation does not leave a mark on the genome). We will discuss mechanisms by which editing affects the proteomic output of the cell, and the functional relevance of editing for immune cells, both at the steady state, and in disease contexts.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Nina Papavasiliou, Rockefeller University"}],"uid":"27964","created_gmt":"2015-12-16 13:20:41","changed_gmt":"2017-04-13 21:17:23","author":"Jasmine Martin","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2016-01-21T15:00:00-05:00","event_time_end":"2016-01-21T15:00:00-05:00","event_time_end_last":"2016-01-21T15:00:00-05:00","gmt_time_start":"2016-01-21 20:00:00","gmt_time_end":"2016-01-21 20:00:00","gmt_time_end_last":"2016-01-21 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"1275","name":"School of Biological Sciences"}],"categories":[],"keywords":[{"id":"5079","name":"Eric Gaucher"},{"id":"168153","name":"Nina Papavasiliou"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EIf you have questions about logistics or would like to set up an appointment with the speaker, please contact the School of Biology\u0027s administrative office at \u003Ca href=\u0022mailto:bio-admin@biology.gatech.edu\u0022\u003Ebio-admin@biology.gatech.edu\u003C\/a\u003E.\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}