{"449421":{"#nid":"449421","#data":{"type":"event","title":"Matthias Fischer, Max Planck Heidelberg","body":[{"value":"\u003Cp\u003EViruses of viruses: the mutualistic relationship between virophages and their protist hosts\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EAbstract:\u003C\/p\u003E\u003Cp\u003EVirophages are double-stranded DNA viruses with 20-30 kilobase pair (kbp) long genomes that replicate inside single-celled eukaryotes such as amoebae and flagellates. Their propagation depends on a co-infecting giant DNA virus of the family \u003Cem\u003EMimiviridae\u003C\/em\u003E, because virophages replicate within the cytoplasmic virion factory of the giant DNA virus. Virophages act as parasites of giant viruses and increase the survival rates of their host cells in the presence of giant viruses. In this talk, I will show that the mavirus virophage is able to integrate its genome into the nuclear genome of its host, the marine flagellate \u003Cem\u003ECafeteria roenbergensis\u003C\/em\u003E. Integrated provirophages are then reactivated and produce infectious virions in response to infection by the giant virus CroV. Virophages thus protect their hosts from lytic giant viruses, while integration into the host genome enables the virophage to persist for prolonged periods of time.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Matthias Fischer, Max Planck Heidelberg"}],"uid":"27964","created_gmt":"2015-09-17 16:38:11","changed_gmt":"2017-04-13 21:18:14","author":"Jasmine Martin","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-10-09T12:00:00-04:00","event_time_end":"2015-10-09T12:00:00-04:00","event_time_end_last":"2015-10-09T12:00:00-04:00","gmt_time_start":"2015-10-09 16:00:00","gmt_time_end":"2015-10-09 16:00:00","gmt_time_end_last":"2015-10-09 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"1275","name":"School of Biological Sciences"}],"categories":[],"keywords":[{"id":"11599","name":"Joshua Weitz"},{"id":"141701","name":"Matthias Fischer"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EIf you have questions about logistics or would like to set up an appointment with the speaker, please contact the School of Biology\u0027s administrative office at \u003Ca href=\u0022mailto:bio-admin@biology.gatech.edu\u0022\u003Ebio-admin@biology.gatech.edu\u003C\/a\u003E.\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}