{"42947":{"#nid":"42947","#data":{"type":"event","title":"Familial aggregation of multivariate traits: testing \u0026 var. selection","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ETITLE:\u003C\/strong\u003E Familial aggregation of multivariate traits:  testing and variable selection \n\u003C\/p\u003E\n\u003Cp\u003E\u003Cstrong\u003ESPEAKER:\u003C\/strong\u003E Professor Yixin Fang\n\u003C\/p\u003E\n\u003Cp\u003E\u003Cstrong\u003EABSTRACT:\u003C\/strong\u003E\n\u003C\/p\u003E\n\u003Cp\u003EIn genetic epidemiology, the first and foremost task is testing for familial aggregation; if no familial aggregation is found, it is unnecessary to conduct further genetic analysis. For multivariate traits, we propose a test statistic, which is actually the leading principal component of heritability. The p-value can be obtained by a permutation procedure or a theorem of Johnstone and Forrester (2004). Furthermore, if the test is significant, it is desired to get rid of those redundant traits to avoid overfitting. To this aim, a cross-validation approach and its approximation are proposed. The talk concludes with some discussion on testing for familial aggregation of functional traits and an application to the cholesterol data from Framingham Heart Study.\n\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"Familial aggregation of multivariate traits:  testing and variable selection","format":"limited_html"}],"field_summary_sentence":[{"value":"Familial aggregation of multivariate traits: testing \u0026 var. selection"}],"uid":"27187","created_gmt":"2009-10-12 20:36:34","changed_gmt":"2016-10-08 01:47:17","author":"Anita Race","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2009-02-26T10:00:00-05:00","event_time_end":"2009-02-26T11:00:00-05:00","event_time_end_last":"2009-02-26T11:00:00-05:00","gmt_time_start":"2009-02-26 15:00:00","gmt_time_end":"2009-02-26 16:00:00","gmt_time_end_last":"2009-02-26 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"1242","name":"School of Industrial and Systems Engineering (ISYE)"}],"categories":[],"keywords":[{"id":"5379","name":"familial aggregation"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cstrong\u003ENicoleta Serban\u003C\/strong\u003E\u003Cbr \/\u003EISyE\u003Cbr \/\u003E\u003Ca href=\u0022mailto:nserban@isye.gatech.edu\u0022\u003EContact Nicoleta Serban\u003C\/a\u003E\u003Cbr \/\u003E\u003Cstrong\u003E404-385-7255\u003C\/strong\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}