{"427721":{"#nid":"427721","#data":{"type":"event","title":"PhD Defense Presentation- He Zheng","body":[{"value":"\u003Cp class=\u0022xmsonormal\u0022\u003E\u003Cstrong\u003EAdvisor:\u003C\/strong\u003E\u0026nbsp;Garrett Stanley, PhD (Georgia Institute of Technology)\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u003Cstrong\u003ECommittee Members:\u003C\/strong\u003E\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003EDieter Jaeger, PhD (Georgia Institute of Technology \u0026amp; Emory University)\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003ERobert Liu, PhD (Georgia Institute of Technology \u0026amp; Emory University)\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003EChristopher Rozell, PhD (Georgia Institute of Technology \u0026amp; Emory University)\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003EAnna Roe, PhD (Vanderbilt University)\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u003Cstrong\u003EState-dependent information processing in the rat vibrissa pathway\u003C\/strong\u003E\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003ETo navigate the world, we must\u0026nbsp;efficiently extract relevant information from\u0026nbsp;complex sensory inputs\u0026nbsp;to form perceptions and make decisions on a moment-to-moment basis. The efficient encoding of sensory information necessarily relies on the ability of the pathway to dynamically interpret the sensory input according to the context under which external stimuli are processed. Internally, this context is represented by the state of the brain, which can be modulated by bottom-up processes such as sensory adaptation, intrinsic mechanisms such as neuromodulators, and top-down processes such as arousal.\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u0026nbsp;This thesis examines the modulation of brain state induced via bottom-up sensory adaptation and the spontaneous change in brain state, the relationship between brain state and sensory-evoked activity, and the potential implications of brain state modulation for the perception of the stimulus.\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003E\u0026nbsp;Using voltage-sensitive dye imaging in anesthetized rats and the paradigm of detection \/ spatial discrimination task by the ideal observer, I\u0026nbsp;quantified, in the adapted state,\u0026nbsp;how the cortical response to a stimulus in the vibrissa pathway was shaped and how the information for detecting and spatially discriminating the stimulus was differentially optimized. Cortical activation and detection \/ discrimination tradeoff were quantified in relation to the degree of adaptation, which was modulated continuously by the frequency and velocity of the adapting stimulus. I\u0026nbsp;investigated the spontaneous changes in brain state reflected in the frequency content and phase of the pre-stimulus activity and how it modulated sensory evoked response. Finally, I explored the interaction between the intrinsic changes in brain state and sensory adaptation.\u0026nbsp;\u003C\/p\u003E\u003Cp class=\u0022xmsonormal\u0022\u003EThis thesis investigates the regulation of brain state\u0026nbsp;via bottom-up sensory adaptation and spontaneous changes, providing a glimpse into a high-dimensional continuum.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EPhD Defense Presentation-\u0026nbsp;\u0022State-dependent information processing in the rat vibrissa pathway\u0022- He Zheng\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022State-dependent information processing in the rat vibrissa pathway\u0022"}],"uid":"27917","created_gmt":"2015-07-22 13:46:54","changed_gmt":"2017-04-13 21:19:02","author":"Laura Paige","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-08-05T10:00:00-04:00","event_time_end":"2015-08-05T12:01:00-04:00","event_time_end_last":"2015-08-05T12:01:00-04:00","gmt_time_start":"2015-08-05 14:00:00","gmt_time_end":"2015-08-05 16:01:00","gmt_time_end_last":"2015-08-05 16:01:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003ELaura Paige\u003C\/p\u003E\u003Cp\u003E404-385-6655\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}