{"418781":{"#nid":"418781","#data":{"type":"event","title":"Breakfast Club Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022From Mechanosensitive Genes \u0026amp; Epigenetics To Nanomedicine: Going with the Flow to Develop Novel Anti-atherogenic Therapies\u0022\u003Cbr \/\u003E\u003Cbr \/\u003EHanjoong Jo, Ph.D.\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EJohn and Jan Portman Professor of Biomedical Engineering\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EWallace H. Coulter Department of Biomedical Engineering and the Division of Cardiology\u003Cbr \/\u003E\u003C\/strong\u003E\u003Cstrong\u003EEmory University and Georgia Tech\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u003Cbr \/\u003E\u003C\/strong\u003ERESEARCH INTERESTS\u003C\/p\u003E\u003Cp\u003EVascular Mechanobiology and Nanomedicine, Role of mechanosensitive genes, miRNAs and epigenetics in atherosclerosis, RNA-based therapeutics, nanomedicine, endothelial mechanobiology\u003C\/p\u003E\u003Cp\u003EFrom Mechanobiology to RNA-based Therapeutics and Nanomedicine: Hanjoong Jo and his lab study how mechanical force associated with blood flow regulates vascular biology and cardiovascular disease, especially atherosclerosis, aortic valve (AV) calcification, and abdominal aortic aneurysms. His lab developed a mouse model of flow-induced atherosclerosis and in vitro shear stress systems to understand the role of flow in endothelial cells and atherosclerosis. Using the animal model, his lab discovered numerous mechanosensitive genes (mRNAs and microRNAs) that are regulated by disturbed flow and their role in atherosclerosis and AV calcification. Recently, his lab has shown that disturbed flow regulates mechanosensitive genes by controlling epigenomic DNA methylation patterns and that inhibition of a key enzyme DNMT by 5-Aza-deoxycytidine can prevent atherosclerosis in mice. His lab has begun taking steps to translate these animal studies toward the clinic by developing better gene and drug therapies using nanotechnology-based delivery approaches and better therapeutic strategies.\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Petit Institute Breakfast Club seminar series was started with the spirit of the Institute\u0027s interdisciplinary mission in mind and started to feature local Petit Institute faculty member\u0027s research in a seminar format. Faculty are often asked to speak at other universities and conferences, but rarely present at their home institution, this seminar series is an attempt to close that gap. The Petit Institute Breakfast Club is open to anyone in the bio-community.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022From Mechanosensitive Genes \u0026 Epigenetics To Nanomedicine: Going with the Flow to Develop Novel Anti-atherogenic Therapies\u0022 - Hanjoong Jo, Ph.D. - Emory University \/ Georgia Tech"}],"uid":"27195","created_gmt":"2015-06-26 09:21:03","changed_gmt":"2017-04-13 21:19:10","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-09-08T09:30:00-04:00","event_time_end":"2015-09-08T10:30:00-04:00","event_time_end_last":"2015-09-08T10:30:00-04:00","gmt_time_start":"2015-09-08 13:30:00","gmt_time_end":"2015-09-08 14:30:00","gmt_time_end_last":"2015-09-08 14:30:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"70917":{"id":"70917","type":"image","title":"Breakfast Club Seminar Series","body":null,"created":"1449177328","gmt_created":"2015-12-03 21:15:28","changed":"1475894625","gmt_changed":"2016-10-08 02:43:45","alt":"Breakfast Club Seminar Series","file":{"fid":"193471","name":"logobldg_graphic.png","image_path":"\/sites\/default\/files\/images\/logobldg_graphic_0.png","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/images\/logobldg_graphic_0.png","mime":"image\/png","size":241588,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/logobldg_graphic_0.png?itok=34gqHmzX"}}},"media_ids":["70917"],"related_links":[{"url":"http:\/\/jolab.gatech.edu\/","title":"Jo lab"},{"url":"http:\/\/petitinstitute.gatech.edu\/breakfast-club","title":"Breakfast Club Seminar schedule"}],"groups":[{"id":"1254","name":"Wallace H. Coulter Dept. of Biomedical Engineering"},{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"11879","name":"BK Club"},{"id":"1808","name":"graduate students"},{"id":"248","name":"IBB"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:colly.mitchell@ibb.gatech.edu\u0022\u003EColly Mitchell\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}