{"393871":{"#nid":"393871","#data":{"type":"event","title":"SINGLE MOLECULE MECHANICS \u2013 TOWARDS HIGH THROUGHPUT.","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003ESchool of Physics Colloquium: Prof. Michelle Wang, Cornell University\u003C\/strong\u003E\u003Cbr \/\u003E\u003C\/p\u003E\u003Cp\u003EOptical trapping has been proven to be a powerful manipulation and measurement technique widely used in the biological and materials sciences.\u0026nbsp;\u0026nbsp;A prominent example of the application of optical trapping techniques is in the study of single biological molecules, in which the mechanical behavior of a molecule can be investigated.\u0026nbsp; These techniques make it possible to disrupt protein complexes with piconewton forces and track motor proteins with nanometer and millisecond resolution.\u0026nbsp; However, conventional optical trapping instruments are only capable of manipulating one molecule at a time, which limits their throughput.\u0026nbsp;\u0026nbsp;Miniaturizing optical trap instruments onto optofluidic platforms holds promise for high-throughput lab-on-a-chip applications.\u0026nbsp;\u0026nbsp;We have been developing novel nanophotonic platforms for precision manipulation and measurements of a bio-molecular array.\u0026nbsp; In addition to on-chip optical trapping, we demonstrate that such a platform can be integrated with fluorescence and laminar flow cells, substantially enhancing its utility.\u0026nbsp; We anticipate that this approach\u0026nbsp;will make single molecule measurements broadly available.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"SINGLE MOLECULE MECHANICS \u2013 TOWARDS HIGH THROUGHPUT."}],"uid":"27664","created_gmt":"2015-04-06 10:04:15","changed_gmt":"2017-04-13 21:19:34","author":"Alison Morain","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-04-20T15:00:00-04:00","event_time_end":"2015-04-20T16:00:00-04:00","event_time_end_last":"2015-04-20T16:00:00-04:00","gmt_time_start":"2015-04-20 19:00:00","gmt_time_end":"2015-04-20 20:00:00","gmt_time_end_last":"2015-04-20 20:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"126011","name":"School of Physics"}],"categories":[],"keywords":[{"id":"168038","name":"SINGLE MOLECULE MECHANICS"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:alison.morain@physics.gatech.edu\u0022\u003Ealison.morain@physics.gatech.edu\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}