{"376651":{"#nid":"376651","#data":{"type":"event","title":"Biomedical Engineering Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u201cTowards Systems-Level Understanding of Immune Cell-Cell Communication and Inflammatory Tissue Environments: Applications in HIV\u201d\u0026nbsp; \u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u003Cstrong\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u003Cstrong\u003EKelly Arnold, Ph.D.*\u003C\/strong\u003E\u003Cstrong\u003E\u003Cbr \/\u003E \u003C\/strong\u003E\u003Cstrong\u003EPostdoctoral Fellow\u003C\/strong\u003E\u003Cstrong\u003E\u003Cbr \/\u003E \u003C\/strong\u003E\u003Cstrong\u003EDepartment of Biomedical Engineering\u003Cbr \/\u003E Massachusetts Institute of Technology\u003C\/strong\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003ESeminar\u0026nbsp;will be made available via videoconference in the Health Sciences Research Building, room E 182 and Technology Enterprise Park, room 104, also on your computer at \u003Ca href=\u0022http:\/\/vidyo.bme.gatech.edu\u0022\u003Ehttp:\/\/vidyo.bme.gatech.edu\u003C\/a\u003E.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EComplex networks of immune cell interactions play a pivotal role in infectious disease, wound healing, autoimmune disease, drug toxicity, cardiovascular disease, and success of regenerative medicine endeavors.\u0026nbsp; Our current understanding of immune function is largely limited to individual cell types, generally lacking contextual considerations of the broader network of cell-cell interactions in tissues that collectively drive physiological behavior.\u0026nbsp; Our inability to combat HIV and other complex emerging pathogens with traditional single-target approaches highlight our limited understanding of immune function and motivate shifting from the current univariate paradigm to a multivariate \u201cmany components at once\u201d, or systems concept for design of new strategies based on systems-level properties of immune function.\u0026nbsp; We employ an integrative approach based on models and measurements made from systems of human cells and tissues to gain new insight into immune cell-cell interaction networks in tissue environments.\u0026nbsp; Specifically, we have used data-driven modeling approaches to reveal novel multivariate cellular and molecular immune response relationships driving immune function in HIV,\u0026nbsp; including 1) alterations in cytokine communication networks of HIV-infected individuals that are independent of CD4+ T cell depletion;\u0026nbsp; 2) complex tissue environments associated with HIV susceptibility in the female genital tract; and 3) multivariate cytokine profiles that promote production of neutralizing antibodies.\u0026nbsp; We believe these approaches can be easily translated to provide a fresh and useful perspective in a broad range of healthcare applications, and used to generate new principles for therapeutic strategies and diagnostic tools based on systems-level properties of immune function.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EFaculty Host: \u003Ca href=\u0022https:\/\/bme.gatech.edu\/bme\/faculty\/Manu-O-Platt\u0022\u003EManu Platt\u003C\/a\u003E, Ph.D.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBiomedical Engineering Seminar - \u0022Towards Systems-Level Understanding of Immune Cell-Cell Communication and Inflammatory Tissue Environments: Applications in HIV \u0022 -\u0026nbsp; Kelly Arnold, Ph.D., Massachusetts Institute of Technology.\u003C\/p\u003E\u0026nbsp;","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Towards Systems-Level Understanding of Immune Cell-Cell Communication and Inflammatory Tissue Environments: Applications in HIV \u0022 -  Kelly Arnold, Ph.D., Massachusetts Institute of Technology"}],"uid":"27159","created_gmt":"2015-02-10 14:48:01","changed_gmt":"2017-04-13 21:20:07","author":"Vickie Okrzesik","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-02-17T10:00:00-05:00","event_time_end":"2015-02-17T11:00:00-05:00","event_time_end_last":"2015-02-17T11:00:00-05:00","gmt_time_start":"2015-02-17 15:00:00","gmt_time_end":"2015-02-17 16:00:00","gmt_time_end_last":"2015-02-17 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"1254","name":"Wallace H. Coulter Dept. of Biomedical Engineering"}],"categories":[],"keywords":[{"id":"1613","name":"Biomedical Engieering"},{"id":"13431","name":"HIV"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EFaculty Host: \u003Ca href=\u0022mailto:manu.platt@gatech.edu\u0022\u003EManu Platt\u003C\/a\u003E, Ph.D.\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}