{"363581":{"#nid":"363581","#data":{"type":"event","title":"Biomedical Engineering Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Systems Genetics in Humans and Mice to Understand Cardiometabolic Diseases\u0022\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EMete Civelek, Ph.D.\u003C\/strong\u003E\u003Cstrong\u003E\u003Cbr \/\u003E Postdoctoral Fellow\u003Cbr \/\u003E David Geffen School of Medicine\u003C\/strong\u003E\u003Cbr \/\u003E \u003Cstrong\u003EUniversity of California, Los Angeles\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003ESeminar\u0026nbsp;will be made available via videoconference in the Health Sciences Research Building, room E 160 and Technology Enterprise Park, room 104.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EMetabolic Syndrome is a group of risk factors that raise the risk for heart disease and diabetes. These risk factors have a significant genetic component. Genome-wide association studies (GWAS) have identified numerous genomic loci associated with the complex cardiometabolic traits. However, the molecular mechanisms of how the genes in these loci affect these complex traits are usually not known suggesting that key pathways leading to increased risk are yet to be discovered. We characterized a population of Finnish Men for metabolic traits and molecular phenotypes. Using a systems genetics approach, we identified regulatory pathways that are perturbed by genetic loci associated with metabolic disorders in humans and mice. We also observed sex specific differences in some of the regulatory pathways. Our studies highlight the power of GWAS across species and systems genetics approaches for dissecting genetics of complex traits.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EFaculty Host: \u003Ca href=\u0022https:\/\/bme.gatech.edu\/bme\/faculty\/Michael-Davis\u0022\u003EMike Davis, Ph.D\u003C\/a\u003E\u003Cstrong\u003E\u003Ca href=\u0022https:\/\/bme.gatech.edu\/bme\/faculty\/Michael-Davis\u0022\u003E.\u003C\/a\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EBiomedical Engineering Seminar - \u201cSystems Genetics in Humans and Mice to Understand Cardiometabolic Diseases\u201d - Mete Civelek, Ph.D., University of California, Los Angeles\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u201cSystems Genetics in Humans and Mice to Understand Cardiometabolic Diseases\u201d - Mete Civelek, Ph.D. - University of California"}],"uid":"27159","created_gmt":"2015-01-13 09:01:49","changed_gmt":"2017-04-13 21:20:39","author":"Vickie Okrzesik","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2015-01-22T10:00:00-05:00","event_time_end":"2015-01-22T11:00:00-05:00","event_time_end_last":"2015-01-22T11:00:00-05:00","gmt_time_start":"2015-01-22 15:00:00","gmt_time_end":"2015-01-22 16:00:00","gmt_time_end_last":"2015-01-22 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"1254","name":"Wallace H. Coulter Dept. of Biomedical Engineering"}],"categories":[],"keywords":[{"id":"1613","name":"Biomedical Engieering"},{"id":"7104","name":"cardiovascular"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"78771","name":"Public"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EFaculty Host: \u003Ca href=\u0022mailto:mdavis41@mail.gatech.edu\u0022\u003EMike Davis, Ph.D.\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}