{"338731":{"#nid":"338731","#data":{"type":"event","title":"Collective Mechanics of Epithelial Cells","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Collective Mechanics of Epithelial Cells\u0022\u003Cbr \/\u003E\u003Cbr \/\u003EAaron F. Mertz, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003ENational Science Foundation Postdoctoral Research Fellow in Biology\u003Cbr \/\u003ERockefeller University\u003C\/strong\u003E\u003Cbr \/\u003E \u003Cbr \/\u003EIndividual cells interact mechanically to regulate myriad biological processes. Mechanical cooperation of cells is evident in dynamic processes such as muscle contraction and flow-induced alignment of vascular cells. Cells\u2019 mechanical interactions also influence tissues\u2019 static material properties, including elastic modulus, surface tension, and fracture toughness. Little is known about how these tissue-scale mechanical phenomena emerge from interactions at molecular and cellular levels. Employing skin cells and skin tissue, we utilize tools of cell biology, mechanical engineering, and theoretical physics to delineate how a tissue cannot be understood simply as an assembly of single cells. Specifically, we show how multicellular colonies collectively apply force to their surroundings, exhibit a property reminiscent of surface tension, and de-mix according to differential intercellular adhesion. Finally, we explore cell proliferation and morphogenesis in developing epidermis in order to understand how a stratified epithelium is built mechanically in vivo. Our findings have implications for mechanical regulation of epithelial cells during development, homeostasis, and disease.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u0022Collective Mechanics of Epithelial Cells\u0022 -\u0026nbsp;Aaron F. Mertz, PhD - Rockefeller University\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Aaron F. Mertz, PhD - Rockefeller University"}],"uid":"27195","created_gmt":"2014-10-31 09:11:12","changed_gmt":"2017-04-13 21:21:18","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-11-10T10:00:00-05:00","event_time_end":"2014-11-10T11:00:00-05:00","event_time_end_last":"2014-11-10T11:00:00-05:00","gmt_time_start":"2014-11-10 15:00:00","gmt_time_end":"2014-11-10 16:00:00","gmt_time_end_last":"2014-11-10 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:andres.garcia@me.gatech.edu\u0022\u003EAndr\u00e9s Garc\u00eda, PhD\u003C\/a\u003E - faculty host\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}