{"321651":{"#nid":"321651","#data":{"type":"event","title":"Chemical Biology Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Cu, Zn Superoxide Dismutase and ALS: To Charge or Not to Charge?\u0022 \u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cstrong\u003EBryan Shaw, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EBaylor University\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003EHistorically, small molecule drugs have been designed to permute the function of a protein by targeting parameters such as Km, Vmax, Kd, or \u2206Gf\u2021. One parameter\u2014a protein\u2019s net electrostatic charge (Z)\u2014has been categorically overlooked as a medicinal \u201ctarget\u201d. Can we design drugs to target a protein\u2019s net charge, for example a drug that boosts the net charge of a protein in order to inhibit its amyloidogenesis and cellular permeability? This talk will discuss the rationale and initial testing of this \u201ccharge boosting\u201d hypothesis within the context of amyotrophic lateral sclerosis (ALS) that is caused by the self-assembly of Cu, Zn superoxide dismutase (SOD1). At the end of the presentation, a new hypothesis on the chemical etiology of sporadic ALS will also be presented (see Shi, Y., et al., J. Am. Chem. Soc. 2013; 135(42):15897-908).\u003Cbr \/\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EChemical Biology Seminar -\u0026nbsp;\u0022Cu, Zn Superoxide Dismutase and ALS: To Charge or Not to Charge?\u0022 - Bryan Shaw, PhD - Baylor University\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Cu, Zn Superoxide Dismutase and ALS: To Charge or Not to Charge?\u0022 - Bryan Shaw, PhD - Baylor University"}],"uid":"27195","created_gmt":"2014-09-04 12:26:32","changed_gmt":"2017-04-13 21:21:51","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-09-15T12:00:00-04:00","event_time_end":"2014-09-15T13:00:00-04:00","event_time_end_last":"2014-09-15T13:00:00-04:00","gmt_time_start":"2014-09-15 16:00:00","gmt_time_end":"2014-09-15 17:00:00","gmt_time_end_last":"2014-09-15 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.shawlaboratory.com\/","title":"Shaw lab"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:mgfinn@gatech.edu\u0022\u003EMG Finn, PhD\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}