{"319141":{"#nid":"319141","#data":{"type":"event","title":"Integrated Cancer Research Center Seminar","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Protease Signatures in Cancer Diagnostics\u0022 \u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EStefan H. Bossmann, PhD\u003Cbr \/\u003EProfessor,\u0026nbsp;Department of Chemistry\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003ETerry C. Johnson Cancer Center\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EThe Midwestern Institute for Comparative Stem Cell Biology\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EKansas State University\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EThe University of Kansas Cancer Center\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EHonorary Distinguished Professor, Kunming University, Kunming, China\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/strong\u003ENumerous proteases are involved in cancer development and progression including Matrix Metalloproteinases (MMPs), Tissue Serine Proteases, and Cathepsins. We have designed nanoplatforms consisting of fluorescent dyes that are attached to Fe\/Fe3O4 nanoparticles via consensus sequences. Their detection limits when using fluorescence plate reader technology are in the sub-femtomolar range.\u0026nbsp;Based on the expression pattern of up to 20 proteases, we were able to:\u003C\/p\u003E\u003Cul\u003E\u003Cli\u003EDetect early lung and breast cancers (stage 1) in blood serum.\u0026nbsp;\u003C\/li\u003E\u003Cli\u003EDiscern sub-groups in Triple Negative Cancer\u003C\/li\u003E\u003Cli\u003ECharacterize tissue samples from mastectomies\u003C\/li\u003E\u003Cli\u003EObserve post-operative effects in protease expression pattern\u003C\/li\u003E\u003C\/ul\u003E\u003Cp\u003EBased on our recent findings, there is emerging evidence that different cancers feature various \u0022protease signatures,\u0022 meaning that the levels of protease over-expression will differ, depending on the origin and stage of cancer. This permits the diagnosis of various solid tumors at their specific stages.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EGeorgia Tech has been a leader in the development of collaborative approaches to both cancer diagnostics and therapeutics. The mission of the Integrated Cancer Research Center (ICRC) is to facilitate integration of the diversity of technological, computational, scientific and medical expertise at Georgia Tech and partner institutions in a coordinated effort to develop improved cancer diagnostics and therapeutics.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Protease Signatures in Cancer Diagnostics\u0022 - Stefan H. Bossmann, PhD - Kansas State University"}],"uid":"27195","created_gmt":"2014-08-26 09:42:37","changed_gmt":"2017-04-13 21:21:57","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-09-23T17:00:00-04:00","event_time_end":"2014-09-23T18:00:00-04:00","event_time_end_last":"2014-09-23T18:00:00-04:00","gmt_time_start":"2014-09-23 21:00:00","gmt_time_end":"2014-09-23 22:00:00","gmt_time_end_last":"2014-09-23 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.k-state.edu\/chem\/people\/faculty\/bossmann.html","title":"Bossman profile"},{"url":"http:\/\/www.icrc.gatech.edu\/","title":"Integrated Cancer Research Center website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"52061","name":"ICRC Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:john.mcdonald@biology.gatech.edu\u0022\u003EJohn McDonald, PhD\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}