{"233371":{"#nid":"233371","#data":{"type":"event","title":"Integrated Cancer Research Center Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022Regulating Energy and Lipid Metabolism through Pluripotent Transcriptional Networks\u0022\u003Cbr \/\u003E\u003Cbr \/\u003EMartin J. Walsh, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAssociate Professor, Structural and Chemical Biology\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAssociate Professor, Pediatrics, Hepatology\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EAssociate Professor, Genetics and Genomic Sciences\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EMt. Sinai School of Medicine\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003EGlycolysis and lipid biosynthesis are crucial to stem cell behavior, but we know little about the transcriptional regulation of factors driving metabolism in concert with stem cell fate. We demonstrate through use of selective BET-bromodomain inhibitors, and comprehensive RNA-seq and ChIP-seq analysis in mouse embryonic stem cells (ESCs), that Brd4, a master chromatin reader, governs transcription of the core pluripotency network and genes required for lipogenesis. Our studies now show that Brd4 governs glycolysis and lipogenesis at the core of the pluripotency framework of genes and that Brd4 regulates critical nodes of metabolism leading to the production of co-factors needed for modifying the epigenome.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EGeorgia Tech has been a leader in the development of collaborative approaches to both cancer diagnostics and therapeutics. The mission of the Integrated Cancer Research Center (ICRC) is to facilitate integration of the diversity of technological, computational, scientific and medical expertise at Georgia Tech and partner institutions in a coordinated effort to develop improved cancer diagnostics and therapeutics.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022Regulating Energy and Lipid Metabolism through Pluripotent Transcriptional Networks\u0022 - Martin J. Walsh, PhD, Mt. Sinai School of Medicine"}],"uid":"27195","created_gmt":"2013-09-03 10:50:33","changed_gmt":"2017-04-13 21:24:01","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2014-03-25T17:00:00-04:00","event_time_end":"2014-03-25T18:00:00-04:00","event_time_end_last":"2014-03-25T18:00:00-04:00","gmt_time_start":"2014-03-25 21:00:00","gmt_time_end":"2014-03-25 22:00:00","gmt_time_end_last":"2014-03-25 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.mountsinai.org\/profiles\/martin-j-walsh","title":"Walsh lab website"},{"url":"http:\/\/www.ibb.gatech.edu\/icrc-seminars","title":"ICRC Seminar Series schedule"},{"url":"http:\/\/www.icrc.gatech.edu\/","title":"Integrated Cancer Research Center website"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"248","name":"IBB"},{"id":"52061","name":"ICRC Seminar"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[{"id":"78751","name":"Undergraduate students"},{"id":"78761","name":"Faculty\/Staff"},{"id":"174045","name":"Graduate students"}],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:john.mcdonald@biology.gatech.edu\u0022\u003EJohn McDonald, PhD\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}