{"213291":{"#nid":"213291","#data":{"type":"event","title":"Bioengineering Seminar Series","body":[{"value":"\u003Cp\u003E\u003Cstrong\u003E\u0022The Emerging Role of Quantitative Imaging Biomarkers\u0022\u003C\/strong\u003E\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003EPresenting:\u003Cbr \/\u003E\u003Cbr \/\u003EJohn Gore, PhD\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EUniversity Professor of Radiology and Radiological Sciences, Radiology \u0026amp; Radiological Sciences\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EHertha Ramsey Cress Chair in Medicine, School of Medicine\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EProfessor of Biomedical Engineering, Biomedical Engineering\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EProfessor of Physics and Astronomy, Physics \u0026amp; Astronomy\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EProfessor of Molecular Physiology and Biophysics, Molecular Physiology \u0026amp; Biophysics\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EDirector, Institute for Imaging Science, School of Medicine\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EVanderbilt University\u003C\/strong\u003E\u003C\/p\u003E\u003Cp class=\u0022FreeForm\u0022\u003EThe development and applications of quantitative imaging biomarkers are essential goals for modern biomedical imaging science. Imaging biomarkers are growing in their diversity and impact, and are of particular importance in the evaluation of novel drugs and treatments. In cancer, molecular imaging using PET and optical methods report directly on cellular events and characteristics, and are complemented by MRI, CT and US methods that measure downstream effects such as changes in tumor volume, cell density, tissue vascular properties and blood flow. These are being applied in developing new drugs and in clinical trials and are proving useful in cancer management, especially to evaluate treatment response. Integrating multiple data sets from different modalities such as PET and MRI can provide a more comprehensive view of tumor metabolic and physiologic state. In neuroscience, quantitative brain morphometry is used to characterize and distinguish subject groups and identify structural variants in individuals which correlate with behavior and function. PET studies of neurotransmitters and their transporters are well established and provide direct evidence of whether drugs hit specific targets, along with their \u003Cem\u003Ein vivo\u003C\/em\u003E binding properties. Functional MRI based on BOLD (blood oxygen level dependent) signals provides unique insights into neural circuits and inter-regional functional connectivities, which may be quantified to assess changes with treatment, development, degeneration or as an index of severity of disease. Pharmaceutical MRI uses similar measurements to evaluate the actions of drugs and signaling pathways in the brain. In diabetes and metabolic disorders, measures of tissue composition, physiology and metabolism provide quantitative indices of disease risk and progression. Overall, there are numerous such biomarkers under development in many different areas of application in each modality, and these activities define much of the research in current imaging science.\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003E\u0026nbsp;\u003Cbr \/\u003E\u003C\/strong\u003EFaculty host:\u0026nbsp; \u003Ca href=\u0022mailto:xh12@mail.gatech.edu\u0022\u003EXiaoping Hu\u003C\/a\u003E\u003Cstrong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EThe Bioengineering Seminar Series is a joint seminar series between Petit Institute and the Wallace H. Coulter Department of Biomedical Engineering. Seminars\u0026nbsp;are held on Tuesdays or Thursdays between 11am-12pm in Petit Institute 1128 unless otherwise indicated.\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"\u0022The Emerging Role of Quantitative Imaging Biomarkers\u0022 - John Gore, PhD - Vanderbilt University"}],"uid":"27691","created_gmt":"2013-05-15 16:37:03","changed_gmt":"2016-10-08 02:03:36","author":"Karen Cannon","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2013-09-19T12:00:00-04:00","event_time_end":"2013-09-19T13:00:00-04:00","event_time_end_last":"2013-09-19T13:00:00-04:00","gmt_time_start":"2013-09-19 16:00:00","gmt_time_end":"2013-09-19 17:00:00","gmt_time_end_last":"2013-09-19 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"hg_media":{"214201":{"id":"214201","type":"image","title":"Gore2","body":null,"created":"1449180096","gmt_created":"2015-12-03 22:01:36","changed":"1475894876","gmt_changed":"2016-10-08 02:47:56","alt":"Gore2","file":{"fid":"197073","name":"gore2.jpg","image_path":"\/sites\/default\/files\/images\/gore2.jpg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/images\/gore2.jpg","mime":"image\/jpeg","size":8447,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/gore2.jpg?itok=h1dBctgK"}},"141991":{"id":"141991","type":"image","title":"Bioengineering Seminar Series","body":null,"created":"1449178723","gmt_created":"2015-12-03 21:38:43","changed":"1475894774","gmt_changed":"2016-10-08 02:46:14","alt":"Bioengineering Seminar Series","file":{"fid":"194960","name":"website-graphic.png","image_path":"\/sites\/default\/files\/images\/website-graphic_0.png","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/images\/website-graphic_0.png","mime":"image\/png","size":334882,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/website-graphic_0.png?itok=WUFaGD2b"}}},"media_ids":["214201","141991"],"related_links":[{"url":"http:\/\/engineering.vanderbilt.edu\/bio\/john-gore","title":"Gore Lab"},{"url":"http:\/\/www.ibb.gatech.edu\/bioe-seminars","title":"BIOE Seminar Series schedule"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"11877","name":"BioE Seminar"},{"id":"36591","name":"Bioengeneering Seminar Series"},{"id":"248","name":"IBB"},{"id":"66461","name":"John Gore"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:xh12@mail.gatech.edu\u0022\u003EXiaoping Hu, PhD - faculty host\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}