{"211731":{"#nid":"211731","#data":{"type":"news","title":"Biomaterial Shows Promise for Type 1 Diabetes Treatment","body":[{"value":"\u003Cp\u003EResearchers have made a significant first step with newly engineered biomaterials for cell transplantation that could help lead to a possible cure for Type 1 diabetes, which affects about 3 million Americans.\u003C\/p\u003E\u003Cp\u003EGeorgia Tech engineers and Emory University clinicians have successfully engrafted insulin-producing cells into a diabetic mouse model, reversing diabetic symptoms in the animal in as little as 10 days.\u003C\/p\u003E\u003Cp\u003EThe research team engineered a biomaterial to protect the cluster of insulin-producing cells \u2013 donor pancreatic islets \u2013 during injection. The material also contains proteins to foster blood vessel formation that allow the cells to successfully graft, survive and function within the body.\u003C\/p\u003E\u003Cp\u003E\u201cIt\u2019s very promising,\u201d said \u003Ca href=\u0022http:\/\/www.me.gatech.edu\/faculty\/garcia\u0022\u003EAndr\u00e9s\u0026nbsp;Garcia\u003C\/a\u003E, Georgia Tech professor of mechanical engineering. \u201cThere is a lot of excitement because not only can we get the islets to survive and function, but we can also cure diabetes with fewer islets than are normally needed.\u201d\u003C\/p\u003E\u003Cp\u003EThe \u003Ca href=\u0022http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0142961213002949\u0022\u003Eresearch article\u003C\/a\u003E \u2013 a partnership with Emory\u2019s \u003Ca href=\u0022http:\/\/www.bme.gatech.edu\/facultystaff\/faculty_record.php?id=46\u0022\u003EDr. Robert Taylor\u003C\/a\u003E and \u003Ca href=\u0022http:\/\/www.ibb.gatech.edu\/peter-thule\u0022\u003EDr. Peter Thule\u003C\/a\u003E that was funded in part by the \u003Ca href=\u0022http:\/\/jdrf.org\/\u0022\u003EJDRF\u003C\/a\u003E, the leading global organization funding Type 1 diabetes research \u2013 will be published in the June issue of the journal \u003Cem\u003EBiomaterials\u003C\/em\u003E.\u003C\/p\u003E\u003Cp\u003EOrganizations such as JDRF\u0026nbsp;are dedicated to finding a cure for Type 1 diabetes, a chronic disease that occurs when the pancreas produces little or no insulin, a hormone that allows the transport of sugar and other nutrients into tissues where they are converted to energy needed for daily life.\u003C\/p\u003E\u003Cp\u003EPancreatic islet transplantation re-emerged as a promising therapy in the late 1990s. Patients with diabetes typically find it difficult to comply with multiple daily insulin injections, which only partially improve long-term outcomes. Successful islet transplantation would remove the need for patients to administer insulin. While islet transplantation trials have had some success, and control of glucose levels is often improved, diabetic symptoms have returned in most patients and they have had to revert to using some insulin.\u003C\/p\u003E\u003Cp\u003EUnsuccessful transplants can be attributed to several factors, researchers say. The current technique of injecting islets directly into the blood vessels in the liver causes approximately half of the cells to die due to exposure to blood clotting reactions. Also, the islets \u2013 metabolically active cells that require significant blood flow \u2013 have problems hooking up to blood vessels once in the body and die off over time.\u003C\/p\u003E\u003Cp\u003EGeorgia Tech and Emory researchers engineered a hydrogel, a material compatible with biological tissues that is a promising therapeutic delivery vehicle. This water-swollen, cross-linked polymer surrounds the insulin-producing cells and protects them during injection. The hydrogel containing the islets was delivered to a new injection site on the outside of the small intestine, thus avoiding direct injection into the blood stream.\u003C\/p\u003E\u003Cp\u003EOnce in the body, the hydrogel degrades in a controlled fashion to release a growth factor protein that promotes blood vessel formation and connection of the transplanted islets to these new vessels. In the study, the blood vessels effectively grew into the biomaterial and successfully connected to the insulin-producing cells.\u003C\/p\u003E\u003Cp\u003EFour weeks after the transplantation, diabetic mice treated with the hydrogel had normal glucose levels, and the delivered islets were alive and vascularized to the same extent as islets in a healthy mouse pancreas. The technique also required fewer islets than previous transplantation attempts, which may allow doctors to treat more patients with limited donor samples. Currently, donor cells from two to three cadavers are needed for one patient.\u003C\/p\u003E\u003Cp\u003EWhile the new biomaterial and injection technique is promising, the study used genetically identical mice and therefore did not address immune rejection issues common to human applications. The research team has funding from JDRF to study whether an immune barrier they created will allow the cells to be accepted in genetically different mice models. If successful, the trials could move to larger animals.\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u201cWe broke up our strategy into two steps,\u201d said Garcia, a member of Georgia Tech\u0027s \u003Ca href=\u0022http:\/\/www.ibb.gatech.edu\/\u0022\u003EPetit Institute for Bioengineering and Bioscience\u003C\/a\u003E. \u201cWe have shown that when delivered in the material we engineered, the islets will survive and graft. Now we must address immune acceptance issues.\u201d\u003C\/p\u003E\u003Cp\u003EMost people with Type 1 diabetes currently manage their blood glucose levels with multiple daily insulin injections or by using an insulin pump. But insulin therapy has limitations. It requires careful measurement of blood glucose levels, accurate dosage calculations and regular compliance to be effective.\u003C\/p\u003E\u003Cp\u003EThis work was also funded by the \u003Ca href=\u0022http:\/\/regenerativeengineeringandmedicine.com\/\u0022\u003ERegenerative Engineering and Medicine Center at Georgia Tech and Emory\u003C\/a\u003E, and the \u003Ca href=\u0022http:\/\/www.actsi.org\/\u0022\u003EAtlanta Clinical and Translation Science Institute \u003C\/a\u003Eunder PHS grant UL RR025008 from the Clinical and Translational Science Award Program.\u003C\/p\u003E\u003Cp\u003EThe \u003Ca href=\u0022http:\/\/www.cphti.gatech.edu\/\u0022\u003ECenter for Pediatric Healthcare Technology Innovation\u003C\/a\u003E at Georgia Tech, \u003Ca href=\u0022http:\/\/www.research.va.gov\/services\/blrd\/merit_review.cfm\u0022\u003Ethe\u0026nbsp;Department of Veterans Affairs Merit Review Program\u003C\/a\u003E and the\u003Ca href=\u0022http:\/\/www.niddk.nih.gov\/\u0022\u003E National Institutes of Health\u2019s National Institute of Diabetes and Digestive and Kidney Diseases\u003C\/a\u003E (Grant R01 DK076801-01) helped fund the project as well.\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u003Cstrong\u003ECITATION: \u003C\/strong\u003EEdward A. Phelps, Devon M. Headen, W. Robert Taylor, Peter M. Thule and Andr\u00e9s J.\u0026nbsp;Garcia. Vasculogenic Bio-Synthetic Hydrogel for Enchancement of Pancreatic Islet Engraftment and Function in Type 1 Diabetes, Biomaterials, June 2013, Pages 4602-4611.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EResearchers have made a significant first step with newly engineered biomaterials for cell transplantation that could help lead to a possible cure for Type 1 diabetes, which affects about 3 million Americans.\u0026nbsp;\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Researchers have made a significant first step with newly engineered biomaterials for cell transplantation that could help lead to a possible cure for Type 1 diabetes, which affects about 3 million Americans."}],"uid":"27462","created_gmt":"2013-05-07 12:48:50","changed_gmt":"2016-10-08 03:14:12","author":"Liz Klipp","boilerplate_text":"","field_publication":"","field_article_url":"","dateline":{"date":"2013-05-08T00:00:00-04:00","iso_date":"2013-05-08T00:00:00-04:00","tz":"America\/New_York"},"extras":[],"hg_media":{"211761":{"id":"211761","type":"image","title":"Professor Andr\u00e9s Garcia - Hydrogel as possible diabetes treatment","body":null,"created":"1449180039","gmt_created":"2015-12-03 22:00:39","changed":"1475894874","gmt_changed":"2016-10-08 02:47:54","alt":"Professor Andr\u00e9s Garcia - Hydrogel as possible diabetes treatment","file":{"fid":"197065","name":"vascularization_r086_hires.jpg","image_path":"\/sites\/default\/files\/images\/vascularization_r086_hires.jpg","image_full_path":"http:\/\/hg.gatech.edu\/\/sites\/default\/files\/images\/vascularization_r086_hires.jpg","mime":"image\/jpeg","size":833544,"path_740":"http:\/\/hg.gatech.edu\/sites\/default\/files\/styles\/740xx_scale\/public\/images\/vascularization_r086_hires.jpg?itok=cZFgk-nM"}}},"media_ids":["211761"],"related_links":[{"url":"http:\/\/www.emory.edu\/home\/index.html","title":"Emory University"},{"url":"http:\/\/www.me.gatech.edu\/","title":"George W. Woodruff School of Mechanical Engineering"}],"groups":[{"id":"1214","name":"News Room"}],"categories":[{"id":"135","name":"Research"}],"keywords":[{"id":"539","name":"Andres Garcia"},{"id":"65991","name":"Biomaterials journal"},{"id":"1612","name":"BME"},{"id":"594","name":"college of engineering"},{"id":"65941","name":"Dr. Peter Thule"},{"id":"65951","name":"Dr. Robert Taylor"},{"id":"2305","name":"Emory University"},{"id":"3356","name":"hydrogel"},{"id":"248","name":"IBB"},{"id":"65981","name":"islet cells"},{"id":"66001","name":"March 2013"},{"id":"65971","name":"transplantation"},{"id":"65961","name":"Type 1 Diabetes"},{"id":"2378","name":"Woodruff School of Mechanical Engineering"}],"core_research_areas":[{"id":"39441","name":"Bioengineering and Bioscience"}],"news_room_topics":[],"event_categories":[],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Cstrong\u003EGeorgia Tech Media Relations\u003C\/strong\u003E\u003Cbr \/\u003ELaura Diamond\u003Cbr \/\u003E\u003Ca href=\u0022mailto:laura.diamond@comm.gatech.edu\u0022\u003Elaura.diamond@comm.gatech.edu\u003C\/a\u003E\u003Cbr \/\u003E404-894-6016\u003Cbr \/\u003EJason Maderer\u003Cbr \/\u003E\u003Ca href=\u0022mailto:maderer@gatech.edu\u0022\u003Emaderer@gatech.edu\u003C\/a\u003E\u003Cbr \/\u003E404-660-2926\u003C\/p\u003E","format":"limited_html"}],"email":["klipp@gatech.edu"],"slides":[],"orientation":[],"userdata":""}}}