{"201161":{"#nid":"201161","#data":{"type":"event","title":"May the force be within you: A tale of the kinesin motor","body":[{"value":"\u003Ch6\u003ESchool of Physics Soft Condensed Matter \u0026amp; Biophysics Semiar Series: Presenting Wonmuk Hwang, Texas A\u0026amp;M University\u003C\/h6\u003E\u003Cp\u003EThe motor protein kinesin uses adenosine triphosphate (ATP) as a fuel and walks along the microtubule filaments in the cell. They are vital for many\u003Cbr \/\u003Ecellular processes including intracellular transport and cell division.\u0026nbsp; Although recent progress in experiments yielded much information regarding\u003Cbr \/\u003Etheir motility, a structure-based, physical mechanism by which the motor amplifies the ATP-driven small conformational change in the motor head into\u003Cbr \/\u003Ea large, 8-nm stepping motion remains largely a mystery. I will discuss molecular dynamics simulations elucidating its force-generation mechanism\u003Cbr \/\u003Eand tests by single-molecule optical trap measurements. We find that the motion consists of autonomous force-generation and guided diffusion, where\u003Cbr \/\u003Ethe partitioning of the two depends on functional needs of different kinesin families.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":"","field_summary_sentence":[{"value":"May the force be within you: A tale of the kinesin motor"}],"uid":"27664","created_gmt":"2013-03-21 10:40:50","changed_gmt":"2016-10-08 02:03:00","author":"Alison Morain","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2013-04-02T16:00:00-04:00","event_time_end":"2013-04-02T17:00:00-04:00","event_time_end_last":"2013-04-02T17:00:00-04:00","gmt_time_start":"2013-04-02 20:00:00","gmt_time_end":"2013-04-02 21:00:00","gmt_time_end_last":"2013-04-02 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"126011","name":"School of Physics"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:alison.morain@physics.gatech.edu\u0022\u003Ealison.morain@physics.gatech.edu\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}