{"191771":{"#nid":"191771","#data":{"type":"event","title":"Dr. Giovanni Bussi, Scuola Internazionale Superiore di Studi Avanzati-SISSA","body":[{"value":"\u003Cp\u003EDr. Giovanni Bussi, Scuola Internazionale Superiore di Studi Avanzati-SISSA\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E\u003Cstrong\u003ERNAs in silico: What can we learn from accelerated molecular simulations\u003C\/strong\u003E\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003ERiboEvo Seminar Series\u003Cem\u003E\u003Cstrong\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003ERibonucleic acid (RNA) is acquiring a larger importance in cell biology, as more functions that it accomplishes are discovered. However, experimental characterization of RNAs dynamical behavior at atomistic level is difficult. Molecular simulations at atomistic details, in combination with state-of-the-art free-energy techniques, can bridge the gap providing an unparalleled perspective on the mechanism and dynamics of RNA folding and conformational transitions.\u003Cbr \/\u003E Recent applications of these techniques to RNA unwinding [1], RNA\/peptide binding [2] and purine riboswitch mechanism of action will be presented.\u003Cbr \/\u003E [1] Colizzi and Bussi, \u0022RNA Unwinding from Reweighted Pulling Simulations\u0022 J. Am. Chem. Soc. (2012), 134, 5173.\u003Cbr \/\u003E [2] Do, Carloni, Varani and Bussi, \u0022RNA\/peptide binding driven by electrostatics - Insight from bi-directional pulling simulations\u0022 J. Chem. Theory Comput. ASAP, doi:10.1021\/ct3009914\u0026nbsp;(2013).\u003C\/p\u003E\u003Cp\u003EFor more information contact \u003Ca href=\u0022mailto:loren.williams@chemistry.gatech.edu\u0022\u003EProf. Loren Williams\u003C\/a\u003E (404-385-6258).\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EDr. Giovanni Bussi, Scuola Internazionale Superiore di Studi Avanzati-SISSA\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E\u003Cstrong\u003ERNAs in silico: What can we learn from accelerated molecular simulations\u003C\/strong\u003E\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003ERiboEvo Seminar Series\u003Cstrong\u003E\u003C\/strong\u003E\u003Cem\u003E\u003Cstrong\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":"","uid":"27275","created_gmt":"2013-02-13 09:46:22","changed_gmt":"2016-10-08 02:02:33","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2013-02-20T15:00:00-05:00","event_time_end":"2013-02-20T16:00:00-05:00","event_time_end_last":"2013-02-20T16:00:00-05:00","gmt_time_start":"2013-02-20 20:00:00","gmt_time_end":"2013-02-20 21:00:00","gmt_time_end_last":"2013-02-20 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EShirley Tomes (404-894-0591) \u003Ca href=\u0022mailto:shirley.tomes@chemistry.gatech.edu\u0022\u003Eshirley.tomes@chemistry.gatech.edu\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}