177571 event 1355413731 1475892095 "Interactome Networks and Human Disease"

Marc Vidal, PhD
Professor & Director
Center for Cancer Systems Biology
Dana Farber Cancer Institute
Harvard Medical School

For over half a century it has been conjectured that macromolecules form complex networks of functionally interacting components, and that the molecular mechanisms underlying most biological processes correspond to particular steady states adopted by such cellular networks. However, until a decade ago, systems-level theoretical conjectures remained largely unappreciated, mainly because of lack of supporting experimental data.

To generate the information necessary to eventually address how complex cellular networks relate to biology, we initiated, at the scale of the whole proteome, an integrated approach for modeling protein-protein interaction or “interactome” networks. Our main questions are: How are interactome networks organized at the scale of the whole cell? How can we uncover local and global features underlying this organization, and how are interactome networks modified in human disease, such as cancer?

]]> Georgia Tech has been a leader in the development of collaborative approaches to both cancer diagnostics and therapeutics. The mission of the Integrated Cancer Research Center (ICRC) is to facilitate integration of the diversity of technological, computational, scientific and medical expertise at Georgia Tech and partner institutions in a coordinated effort to develop improved cancer diagnostics and therapeutics.

]]> 177471 image 195920 image/jpeg John McDonald, PhD

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