{"171301":{"#nid":"171301","#data":{"type":"event","title":"Neural Circuits and Synaptic Mechanosensors as Keys to Brain Repair","body":[{"value":"\u003Cp\u003E\u003Cem\u003EA seminar by\u003Cstrong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003E\u003C\/strong\u003E\u003C\/em\u003E\u003Cstrong\u003ESolomon R. Pollack, PhD\u003C\/strong\u003E\u003Cstrong\u003E\u003Cbr \/\u003EProfessor \u0026amp; Chair\u003C\/strong\u003E\u003Cstrong\u003E\u003Cbr \/\u003EDepartment of Bioengineering\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cstrong\u003EUniversity of Pennsylvania\u003C\/strong\u003E\u003Cbr \/\u003E\u003Cbr \/\u003EMechanical forces influence the development, maintenance, and degeneration of the nervous system at many length scales.\u0026nbsp;\u0026nbsp;In this talk, we identify the molecular domains of the NMDA receptor that regulate its unique mechanosensitivity, and study how this mechanosensitivity is a key aspect that underlies the role of the NMDA receptor in traumatic brain injury (TBI).\u0026nbsp; We use imaging-based methods to study how this receptor mechanosensitivity influences the synchrony of neural circuits, and\u0026nbsp;explore potential upstream therapeutic targets to reverse these mechanically-regulated changes in neural circuits. From these studies, we identify a new therapeutic target that is successful in reducing impairments in a preclinical model of TBI.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003E\u0022Neural Circuits and Synaptic Mechanosensors as Keys to Brain Repair\u0022 - David F. Meaney, PhD - University of Pennsylvania\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"David F. Meaney, PhD - University of Pennsylvania"}],"uid":"27195","created_gmt":"2012-11-15 09:10:49","changed_gmt":"2016-10-08 02:01:17","author":"Colly Mitchell","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2012-11-20T10:00:00-05:00","event_time_end":"2012-11-20T11:00:00-05:00","event_time_end_last":"2012-11-20T11:00:00-05:00","gmt_time_start":"2012-11-20 15:00:00","gmt_time_end":"2012-11-20 16:00:00","gmt_time_end_last":"2012-11-20 16:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.seas.upenn.edu\/directory\/profile.php?ID=64","title":"Meaney profile"}],"groups":[{"id":"1292","name":"Parker H. Petit Institute for Bioengineering and Bioscience (IBB)"}],"categories":[],"keywords":[{"id":"50471","name":"Neural Circuits and Synaptic Mechanosensors as Keys to Brain Repair"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003E\u003Ca href=\u0022mailto:amy.tang@bme.gatech.edu\u0022\u003EAmy Tang\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}