{"165131":{"#nid":"165131","#data":{"type":"event","title":"Prof. Kevin Plaxco, University of California-Santa Barbara","body":[{"value":"\u003Cp\u003EProf. Kevin Plaxco, University of California-Santa Barbara\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E\u003Cstrong\u003EInspired by nature: using protein regulatory mechanisms to build better biosensors\u003C\/strong\u003E\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003EChemistry and Biochemistry Special Seminar\u003C\/p\u003E\u003Cp\u003ERecent years have seen the development of a broad class of optical and electrochemical sensors in which the binding of a specific molecular target is signaled via a large-scale conformational change in a protein- or nucleic-acid-based receptor. The reagentless, rapidly reversible nature of this signaling mechanism supports continuous, real-time measurement of a wide variety of analytes, and, when coupled to electrochemical read-outs, its extraordinary selectivity allows this detection to be performed in even the most grossly complicated samples, such as flowing, undiluted blood serum. Like all processes reliant on single-site binding, however, these sensors still suffer from two potentially significant limitations: the useful dynamic range of single-site receptors is centered at a fixed target concentration (defined by the receptor\u0092s dissociation constant) and spans a fixed width (defined by the hyperbolic shape of the Langmuir isotherm). In this talk, I describe the various mechanisms that evolution has invented in order to circumvent these very same limitations (e.g., allostery, cooperativity, etc.), and demonstrate their value in improving the utility of a wide range of artificial biosensors.\u003C\/p\u003E\u003Cp\u003EFor more information contact \u003Ca href=\u0022mailto:paul.goldbart@physics.gatech.edu\u0022\u003EProf. Paul Goldbart\u003C\/a\u003E (404 894-5200).\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EProf. Kevin Plaxco, University of California-Santa Barbara\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E\u003Cstrong\u003EInspired by nature: using protein regulatory mechanisms to build better biosensors\u003C\/strong\u003E\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003EChemistry and Biochemistry Special Seminar\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Prof. Kevin Plaxco, University of California-Santa Barbara"}],"uid":"27275","created_gmt":"2012-10-25 10:31:26","changed_gmt":"2016-10-08 02:00:53","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2012-11-01T12:00:00-04:00","event_time_end":"2012-11-01T13:00:00-04:00","event_time_end_last":"2012-11-01T13:00:00-04:00","gmt_time_start":"2012-11-01 16:00:00","gmt_time_end":"2012-11-01 17:00:00","gmt_time_end_last":"2012-11-01 17:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.chem.ucsb.edu\/people\/academic\/kevin-w-plaxco","title":"Prof. Kevin Plaxco"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EShirley Tomes (404-894-0591) \u003Ca href=\u0022mailto:shirley.tomes@chemistry.gatech.edu\u0022\u003Eshirley.tomes@chemistry.gatech.edu\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}