{"164091":{"#nid":"164091","#data":{"type":"event","title":"Dr. Amit Reddi, Johns Hopkins University","body":[{"value":"\u003Cp\u003EDr. Amit Reddi, Johns Hopkins University\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E\u003Cstrong\u003EA New Role for An Old Copper Enzyme in Glucose and Oxygen Sensing\u003C\/strong\u003E\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003ECu\/Zn superoxide dismutase (SOD1) is a highly abundant SOD in eukaryotic cells and is in the frontline of defense against reactive oxygen species (ROS) by catalyzing the disproportionation of superoxide radicals into hydrogen peroxide and oxygen. Using the baker\u2019s yeast (Saccharomyces cerevisiae) as a model organism, we now report a new role for SOD1 in transmitting signals from oxygen and glucose to repress respiration. The mechanism involves SOD1-mediated stabilization of two casein kinase 1-gamma (CK1\u03b3) homologues required for respiratory repression. SOD1 binds a C-terminal degron identified in yeast CK1\u03b3 and promotes kinase stability by catalyzing superoxide conversion to peroxide. Our findings suggest that while the bulk of SOD1 is dispensable for antioxidant defense, it is required for metabolic control using signals from superoxide produced during aerobic glycolysis. Thus, in a single circuit, oxygen, glucose, and reactive oxygen can repress respiration through SOD1\/ CK1\u03b3 signaling.\u003C\/p\u003E\u003Cp\u003EFor more information contact \u003Ca href=\u0022mailto:pperalta-yahya@chemistry.gatech.edu\u0022\u003EProf. Pamela Peralta-Yahya\u003C\/a\u003E at (404-894-4228).\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EDr. Amit Reddi, Johns Hopkins University\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E\u003Cstrong\u003EA New Role for An Old Copper Enzyme in Glucose and Oxygen Sensing\u003C\/strong\u003E\u003C\/em\u003E\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Dr. Amit Reddi, Johns Hopkins University"}],"uid":"27275","created_gmt":"2012-10-22 12:01:41","changed_gmt":"2016-10-08 02:00:47","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2012-11-26T15:00:00-05:00","event_time_end":"2012-11-26T16:00:00-05:00","event_time_end_last":"2012-11-26T16:00:00-05:00","gmt_time_start":"2012-11-26 20:00:00","gmt_time_end":"2012-11-26 21:00:00","gmt_time_end_last":"2012-11-26 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EShirley Tomes (404-894-0591) \u003Ca href=\u0022mailto:shirley.tomes@chemistry.gatech.edu\u0022\u003Eshirley.tomes@chemistry.gatech.edu\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}