{"158001":{"#nid":"158001","#data":{"type":"event","title":"Prof. Shelagh Ferguson-Miller, Michigan State University","body":[{"value":"\u003Cp\u003EProf. Shelagh Ferguson-Miller, Michigan State University\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E\u003Cstrong\u003ERole of conformational change and lipidic ligands in function and regulation of Cytochrome c Oxidase\u003C\/strong\u003E\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003ESchool Colloquium\u003C\/p\u003E\u003Cp\u003EAs the consumer of 95% of the oxygen we breathe, cytochrome c oxidase plays a major role in the energy balance of the cell. Regulation of its oxygen reduction and proton pumping activity is therefore critical to physiological function in health and disease. The location and structure of pathways for protons that are required to support cytochrome c oxidase activity are still under debate, including their requirements for conserved residues and waters, and how they are gated to prevent or allow proton backflow. Recent high resolution crystal structures of bacterial and mammalian forms of oxidase reveal conserved positions of water and lipid, as well as a steroid binding site. \u0026nbsp;In addition, significant conformational changes have been resolved, linked to redox state. The findings provide new insights into potential regulatory ligands, proton transfer and gating mechanisms, as well as physiological implications.\u003C\/p\u003E\u003Cp\u003EFerguson-Miller, Shelagh, Hiser, Carrie, Liu, Jian (2012) Gating and regulation of the cytochrome c oxidase proton pump. \u003Cstrong\u003EBiochimica et Biophysica Acta\u003C\/strong\u003E 1817: 489\u2013494\u003C\/p\u003E\u003Cp\u003ELiu, Jian, Qin, Ling, S. Ferguson-Miller (2011) Role of Conformational Change and Conserved Water in the Cytochrome Oxidase Proton Pump: Crystallographic and On-Line Spectral Evidence. \u003Cstrong\u003EProc\u003C\/strong\u003E.\u003Cstrong\u003ENatl\u003C\/strong\u003E.\u003Cstrong\u003EAcad\u003C\/strong\u003E.\u003Cstrong\u003ESci.\u003C\/strong\u003E \u003Cstrong\u003EUSA\u003C\/strong\u003E 108: 1284-1289\u003C\/p\u003E\u003Cp\u003EBuhrow, Leann, Ferguson-Miller, Shelagh, and Kuhn, Leslie A. (2012) \u201cFrom Static Structure to Living Protein: Computational Analysis of Cytochrome \u003Cem\u003Ec \u003C\/em\u003EOxidase Main-chain Flexibility\u201d \u003Cstrong\u003EBiophysical J.\u003C\/strong\u003E 102: 2158-2166\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E\u003Cp\u003EFor more information contact \u003Ca href=\u0022mailto:raquel.lieberman@chemistry.gatech.edu\u0022\u003EProf. Raquel Lieberman\u003C\/a\u003E (404-385-3663).\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EProf. Shelagh Ferguson-Miller, Michigan State University\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E\u003Cstrong\u003ERole of conformational change and lipidic ligands in function and regulation of Cytochrome c Oxidase\u003C\/strong\u003E\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003ESchool Colloquium\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Prof. Shelagh Ferguson-Miller, Michigan State University"}],"uid":"27275","created_gmt":"2012-10-01 11:39:18","changed_gmt":"2016-10-08 02:00:10","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2012-10-18T17:00:00-04:00","event_time_end":"2012-10-18T18:00:00-04:00","event_time_end_last":"2012-10-18T18:00:00-04:00","gmt_time_start":"2012-10-18 21:00:00","gmt_time_end":"2012-10-18 22:00:00","gmt_time_end_last":"2012-10-18 22:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.bch.msu.edu\/faculty\/fmiller.htm","title":"Prof. shelagh Ferguson-Miller"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[{"id":"919","name":"Biochemistry"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EShirley Tomes (404-894-0591) \u003Ca href=\u0022mailto:shirley.tomes@chemistry.gatech.edu\u0022\u003Eshirley.tomes@chemistry.gatech.edu\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}