133331 event 1338461008 1475891937 Presenting:
Wei (Jack) Chen - Advisor, Cheng Zhu, PhD

"Observing Force-regulated Conformational Changes and Ligand Dissociation from a Single Integrin on Living Cells"

An integrin, a cell adhesion receptor, has multiple conformations that regulate integrin’s function. Using a biomembrane force probe, we observed real-time reversible conformational changes of a single integrin on living cells. We determined the dynamics and kinetics of such conformational changes, and quantified how initial and subsequent conformations of integrin regulate the force-dependent dissociation from its ligand.

Ivana Parker - Advisor, Manu Platt, PhD

"Effect of HIV Proteins and Antiretroviral Therapies on Protease Activity and Arterial"

Advances in antiretroviral therapies have extended the lives of HIV+ patients, but they have increased risk of death by cardiovascular disease. We hypothesize that HIV proteins and antiretroviral drugs interact with peripheral blood mononuclear cells (PBMCs) and cells comprising the arterial wall, altering their protease expression and accelerating atherogenesis. Zymography, cell culture, and use of a tg-mouse model allow investigation of this.

]]> The Graduate and Post-Doc (GaP) Seminar Series is a weekly event of research presentations by two graduate students or post-docs conducting bio-related research.  The series is organized and sponsored by the Parker H. Petit Institute for Bioengineering and Bioscience (IBB) with additional support from the Wallace H. Coulter Department of Biomedical Engineering. It is held every Wednesday at 12:00pm in IBB 1128 and refreshments are provided. If your research group or department would like to present at future seminars, please contact Manu Platt, PhD.

]]> 65807 image 192409 image/png 146301 image 195083 image/png 146561 image 195088 image/jpeg Manu Platt, PhD

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