{"112721":{"#nid":"112721","#data":{"type":"event","title":"Prof. Floyd Romesberg, The Scripps Research Institute","body":[{"value":"\u003Cp\u003EProf. Floyd Romesberg, The Scripps Research Institute\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E\u003Cstrong\u003E\u003Cem\u003E\u003Cstrong\u003EEfforts toward the expansion of the genetic alphabet\u003C\/strong\u003E\u003C\/em\u003E\u003C\/strong\u003E\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003EExpansion of the genetic alphabet to include a third base pair would be a fundamental accomplishment that would not only have immediate utility for a number of applications, such as site-specific oligonucleotide labeling, but would also lay the foundation for a semi-synthetic organism.\u0026nbsp; We have developed an unnatural base pair, d\u003Cstrong\u003E5SICS\u003C\/strong\u003E-d\u003Cstrong\u003ENaM\u003C\/strong\u003E, that forms based on packing and hydrophobic interactions rather than complementary H-bonding.\u0026nbsp; d\u003Cstrong\u003E5SICS\u003C\/strong\u003E-d\u003Cstrong\u003ENaM\u003C\/strong\u003E, as well as derivatives with linkers attached for site-specific labeling of DNA or RNA, is replicated and transcribed with excellent efficiency and fidelity.\u0026nbsp; Structural studies, as well as several applications, including ongoing selections for unnatural DNAzymes will be discussed.\u0026nbsp; Finally, we are supplementing these efforts with directed evolution to tailor DNA polymerases to more efficiently replicate DNA containing d\u003Cstrong\u003E5SICS\u003C\/strong\u003E-d\u003Cstrong\u003ENaM\u003C\/strong\u003E.\u003C\/p\u003E\u003Cp\u003EFor more information contact \u003Ca href=\u0022http:\/\/mailto:lyon@chemistry.gatech.edu\u0022\u003EProf. Andrew Lyon\u003C\/a\u003E (404-894-4090).\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EProf. Floyd Romesberg, The Scripps Research Institute\u003C\/p\u003E\u003Cp\u003E\u003Cem\u003E\u003Cstrong\u003EEfforts toward the expansion of the genetic alphabet\u003C\/strong\u003E\u003C\/em\u003E\u003C\/p\u003E\u003Cp\u003E\u0026nbsp;\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":"","uid":"27275","created_gmt":"2012-02-27 16:53:21","changed_gmt":"2016-10-08 01:58:10","author":"Shirley Tomes","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2012-04-27T21:00:00-04:00","event_time_end":"2012-04-27T22:00:00-04:00","event_time_end_last":"2012-04-27T22:00:00-04:00","gmt_time_start":"2012-04-28 01:00:00","gmt_time_end":"2012-04-28 02:00:00","gmt_time_end_last":"2012-04-28 02:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"related_links":[{"url":"http:\/\/www.scripps.edu\/romesberg\/","title":"The Romesberg Lab"}],"groups":[{"id":"85951","name":"School of Chemistry and Biochemistry"}],"categories":[],"keywords":[],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1795","name":"Seminar\/Lecture\/Colloquium"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[{"value":"\u003Cp\u003EShirley Tomes (404-894-0591) \u003Ca href=\u0022mailto:shirley.tomes@chemistry.gatech.edu\u0022\u003Eshirley.tomes@chemistry.gatech.edu\u003C\/a\u003E\u003C\/p\u003E","format":"limited_html"}],"email":[],"slides":[],"orientation":[],"userdata":""}}}