{"112171":{"#nid":"112171","#data":{"type":"event","title":"Jason S. Bach - Ph.D. Defense","body":[{"value":"\u003Cp\u003EDavid Ku, M.D., Ph.D., Co-Advisor\u003Cbr \/\u003EMohammed Cherkaoui, Ph.D., Co-Advisor\u003Cbr \/\u003EDr. Robert E. Guldberg, Ph.D.\u003Cbr \/\u003EDr. Rudolph L. Gleason, Ph.D.\u003Cbr \/\u003EDr. Laurent Corte, Ph.D.\u003C\/p\u003E\u003Cp\u003ERupture of the anterior cruciate ligament (ACL) is a relatively common sports-related injury for which the current treatment is reconstruction with an autograft or allograft.\u0026nbsp; Drawbacks associated with each of the current options would make a prosthetic alternative advantageous, however, artificial ligaments are not widely used, having failed due to lack of biocompatibility and mechanical insufficiencies.\u0026nbsp; To develop the next-generation prosthetic ACL, design control principles were applied including specification of comprehensive design inputs, risk analysis, and verification testing.\u0026nbsp; A design was proposed utilizing polyvinyl alcohol and ultrahigh molecular weight polyethylene, selected for good biocompatibility and mechanical strength and stiffness suitable for ACL replacement.\u0026nbsp; A biomimetic fibrous rope pattern was designed for the intra-articular ligament section of the prosthetic that produced a close match the static tensile behavior of the native ACL and which also demonstrated good resistance to fatigue and creep.\u0026nbsp; A calcium phosphate coating was recommended for the sections of the device lying within the bone tunnel to increase the rate of osseointegration.\u0026nbsp; The proposed design was then evaluated in a computational simulation to assess functional restoration and the effects of installation parameters such as tension and tunnel orientation on knee kinematics.\u0026nbsp; The encouraging results of preclinical verification testing support further in vivo evaluation of the proposed design.\u003C\/p\u003E","summary":null,"format":"limited_html"}],"field_subtitle":"","field_summary":[{"value":"\u003Cp\u003EDesign and Evaluation of a Prosthetic Anterior Cruciate Ligament Replacement Medical Device\u003C\/p\u003E","format":"limited_html"}],"field_summary_sentence":[{"value":"Design and Evaluation of a Prosthetic Anterior Cruciate Ligament Replacement Medical Device"}],"uid":"27547","created_gmt":"2012-02-24 11:01:39","changed_gmt":"2016-10-08 01:58:10","author":"Chris Ruffin","boilerplate_text":"","field_publication":"","field_article_url":"","field_event_time":{"event_time_start":"2012-03-13T14:00:00-04:00","event_time_end":"2012-03-13T17:00:00-04:00","event_time_end_last":"2012-03-13T17:00:00-04:00","gmt_time_start":"2012-03-13 18:00:00","gmt_time_end":"2012-03-13 21:00:00","gmt_time_end_last":"2012-03-13 21:00:00","rrule":null,"timezone":"America\/New_York"},"extras":[],"groups":[{"id":"65448","name":"Bioengineering Graduate Program"}],"categories":[],"keywords":[{"id":"569","name":"bioengineering"}],"core_research_areas":[],"news_room_topics":[],"event_categories":[{"id":"1788","name":"Other\/Miscellaneous"}],"invited_audience":[],"affiliations":[],"classification":[],"areas_of_expertise":[],"news_and_recent_appearances":[],"phone":[],"contact":[],"email":[],"slides":[],"orientation":[],"userdata":""}}}