PhD Proposal by Joseph Del Rosario

Event Details
  • Date/Time:
    • Thursday November 12, 2020
      9:00 am - 11:00 am
  • Location: Remote: Blue Jeans
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  • URL: Bluejeans
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  • Fee(s):
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Summaries

Summary Sentence: : Cortical circuit mechanisms of visual perception in wildtype and transgenic autism model mice

Full Summary: No summary paragraph submitted.

Joseph Del Rosario

BME PhD Thesis Proposal

 

Date:  Nov. 12th, 2020

 

Time: 9-11am ET

 

BlueJeans Link: https://bluejeans.com/158678195?src=join_info

 

Meeting ID: 158 678 195

 

Advisor: Dr. Bilal Haider

 

Committee Members:

Dr. Peter Wenner

Dr. Annabelle Singer

Dr. Garrett Stanley

Dr. Samuel Sober

 

Title: Cortical circuit mechanisms of visual perception in wildtype and transgenic autism model mice

 

Abstract:

Animals use sensory information to make behavioral decisions. This process of sensory-driven behavior (perception) is reliant on coordinated excitatory and inhibitory neural activity acting across numerous cortical areas. Disruptions in coordinated activity can hinder perception and are thought to underlie several neurological disorders, including autism spectrum disorder (ASD). The relationship of specific excitatory and inhibitory neurons to visual perceptual behaviors remains poorly understood. This proposal will investigate the cortical mechanisms underlying correct and incorrect visual perceptual performance in normal wildtype (WT) mice and a transgenic knockout (KO) mouse model of ASD (CNTNAP2-/-) using electrophysiology and optogenetic manipulations across different cortical visual areas (primary visual cortex – V1, higher visual areas – HVAs). Aim 1 will first determine how heterogenous populations of inhibitory neurons (PV+, SST+) uniquely modulate perception. Aim 2 will leverage knowledge of how V1 activity can permit or hinder perception in normal WT mice, to identify the V1 neural deficits that best explain perceptual impairments well-studied KO mouse model of ASD. Aim 3 will determine the role of HVAs for visual perception in WT and KO mice.

Additional Information

In Campus Calendar
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Graduate Studies

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Faculty/Staff, Public, Graduate students, Undergraduate students
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Other/Miscellaneous
Keywords
Phd proposal
Status
  • Created By: Tatianna Richardson
  • Workflow Status: Published
  • Created On: Oct 30, 2020 - 12:54pm
  • Last Updated: Oct 30, 2020 - 12:54pm