Title:  A Novel Multi-Modal, Non- Invasive Sensing System To Automatically Quantify Changes in Extravascular Fluids

Committee: 

Dr. Inan, Advisor 

Dr. Anderson, Chair

Dr. Bhatti

Abstract:

The objective of my proposed research is to investigate non-invasive sensing techniques for robustly monitoring changes in extracellular fluid content of biological tissue. The two causes of extracellular fluid alteration that I will research are from intravenous (IV) catheter dislodgment and swelling following ankle injury. First, a robust and miniature system was designed and implemented by researching different integrated circuits, analog front ends, and novel physiology-driven calibration techniques that together increase the system’s accuracy and reduce its size and power consumption. Next, novel methods and algorithms were developed to allow for unobtrusive real-time detection of changes in extracellular fluid content. The system and the methods were validated in human subjects studies and cadaver models for ankle edema tracking, and in human subjects studies for intravenous infiltration detection.