No Country for Old Mammals: The Comparative Genomics of Mammalian Ageing and Human Longevity

Event Details
  • Date/Time:
    • Thursday October 24, 2019
      10:55 am
  • Location: Room 1005, Roger A. and Helen B. Krone Engineered Biosystems Building (EBB), 950 Atlantic Dr NW, Atlanta, GA 30332
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Summary Sentence: A Biological Sciences Seminar by Arcadi Navarro, Ph.D.

Full Summary: No summary paragraph submitted.

  • Arcadi Navarro Arcadi Navarro

Arcadi Navarro, Ph.D.
Universitat Pompeu Fabra Barcelona

The rapid progress of medical and comparative genomics is affording new data that allow testing hypothesis related to senescence and aging, both within and across species. Recently, we studied the effects of genetic variants associated with complex human diseases appearing at different periods in life, and made observations that fitted the Mutation Accumulation and the Antagonistic Pleiotropy theories of ageing. In particular, we observed higher risk allele frequencies and large effect sizes for late-onset diseases, and detected a significant excess of early–late antagonistically pleiotropic variants. Strikingly, these variants tend to be harboured by genes related to ageing across many species.

These results prompted a set of comparative genomic studies in which, so far, we have focused on coding variation of primates and mammals and on maximum lifespan. We use two different approaches. First, we search for parallel amino-acid mutations that co-occur with increases or reductions in longevity across the primate & mammal lineages. Second, we study how changes in rates of protein evolution correlate with changes in longevity across phylogenies using phylogenetic generalized least squares. Both approaches help identifying genes and pathways related to aging and longevity and, in addition, allow for better interpretation of human longevity data coming from GWAS.

Host: Greg Gibson, Ph.D.

Additional Information

In Campus Calendar

School of Biological Sciences

Invited Audience
Faculty/Staff, Postdoc, Public, Graduate students, Undergraduate students
Arcadi Navarro, Greg Gibson
  • Created By: Jasmine Martin
  • Workflow Status: Published
  • Created On: Sep 11, 2019 - 5:57pm
  • Last Updated: Sep 13, 2019 - 8:42am