Bionanoparticle detects the slightest sign of transplant organ rejection

Bionanoparticle detects the slightest sign of transplant organ rejection

A T cell, here in violet, makes contact with a transplant organ cell, here in brown and purple. The T cell secretes the enzyme granzyme B, here in gray, which attacks the organ cell. But granzyme B also severs fluorescent signal molecules, in green, from the rejection detecting nanoparticle, in light red. The signal molecules makes their way into the urine, where they give off a fluorescent cue.

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News Room, Research Horizons

Categories
Research, Biotechnology, Health, Bioengineering, Genetics, Chemistry and Chemical Engineering, Engineering, Life Sciences and Biology, Nanotechnology and Nanoscience
Keywords
Rejection, transplant, Transplant Failure, transplant complications, Transplant Biology, Organ Rejection, Transplant Rejection, nanoparticle, bionanotechnology, fluorescence, fluorescence detectors, Fluorescent Labeling, Fluorescent Molecules, Biopsy With Needle, biopsy-free diagnosis, Biopsies, Needle Biopsy, Coulter, granzyme B, T cell, early detection, Kidney Transplant, dextran, PEG, polyethylene glycol, Reporter, Infrared imaging, Immunosuppresion, Immunosuppresive, Immunosuppressant, immunosuppressant drugs, immunosuppressant medications, Immunosuppressants, Immunosuppressive
Status
  • Created By: Ben Brumfield
  • Workflow Status: Published
  • Created On: Feb 19, 2019 - 2:51pm
  • Last Updated: Feb 19, 2019 - 2:51pm