Prasad Dasi, Ph.D.*

Associate Professor
Departments of Biomedical Engineering and Surgery
Ohio State University

Wednesday, Feb 20, 2019
10:00 a.m. – 11:00 a.m.
Georgia Tech Whitaker Bldg., McIntire Room 3115

Videoconference
Emory: HSRB E160 / Georgia Tech: TEP, stream from your PC (no conf room)
https://bluejeans.com/809850842

ABSTRACT
Heart valve disease is a major component of heart disease in the western world and more so in the developing world. Although artificial heart valves have prolonged countless lives, critical challenges still remain due to issues surrounding durability, thromboembolic risks, operative risks, and high cost. The rapid adoption of trans-catheter valves has only magnified these issues which in order to be completely addressed require a truly multi-disciplinary and translational collaboration between engineering and medicine. In this talk, I will present our current efforts in this direction that include not only re-engineering heart valves at the device level but also transforming the entire clinical pipeline and relevant guidelines from diagnosis, planning, delivery, and follow-up. Two examples are presented to illustrate: (1) the complex interaction between trans-catheter aortic valves in patient-specific anatomies in the context of developing advanced approaches and guidelines to avoid adverse outcomes such as leaflet thrombosis, coronary obstruction and residual pressure gradients; and (2) the promise of novel biomaterials inspired biomechanical designs towards producing durable, anti-thrombogenic, and low-cost artificial heart valves. Both examples include advancement in state-of-the-art experimental and computational modeling, 3D printing, and integration of biomaterials concepts. Over the long term this research aims to bring precision medicine guidelines based planning and personalization of artificial heart valves for both adult and pediatric applications.

BIOGRAPHY
Prof. Lakshmi Prasad Dasi is an established researcher in the field of prosthetic heart valves, cardiovascular biomechanics, biomaterials, and devices. He is a tenured Associate Professor of Biomedical Engineering, of Surgery, and of Physiology and Cell Biology at The Ohio State University. He is also Affiliate Faculty, Center for Cardiovascular Research, Nationwide Children's Hospital Research Institute; and at the School of Biomedical Engineering of Colorado State University. Prof. Dasi earned his Ph.D. from Georgia Institute of Technology in 2004 with a focus in fluid dynamics and turbulence. He trained as a postdoctoral fellow and research engineer under Prof. Ajit Yoganathan’s mentorship at Georgia Tech. In 2009, he established the Cardiovascular Biofluid Mechanics Lab (CBFL) as Assistant Professor at Colorado State University and moved to The Ohio State University in 2015 as his focus became more translational. Since then, his research has focused on tackling the complexity of: (a) prosthetic heart valve engineering (conventional & trans-catheter); (b) heart valve biomechanics (native and prosthetic); (c) structure-function mechano-biological relationships of the heart in health and disease at the embryonic, pediatric, as well as adult stages; and (d) turbulence and turbulent blood flow. Dr. Dasi has over 75 journal publications and 8 patents and is actively involved in commercialization new trans-catheter heart valves as well as predictive computational models for valve therapy. His research has been funded by the National Institutes of Health (NIH), National Science Foundation (NSF), American Heart Association (AHA), the States of Colorado and Ohio, as well as philanthropic individuals.

Host: Wei Sun