School of Physics - Soft Condensed Matter Seminar featuring Jeff Wereszczynski

Event Details
  • Date/Time:
    • Wednesday December 13, 2017
      3:00 pm - 4:00 pm
  • Location: School of Physics (Howey Building), Room N110, 837 State Street Atlanta, Georgia 30332
  • Phone:
  • URL: School of Physics (Howey Building)
  • Email:
  • Fee(s):
    N/A
Contact

JC Gumbart - Assistant Professor

404-385-0797

Summaries

Summary Sentence: Join the School of Physics as they present their Soft Condensed Matter Seminar featuring guest speaker Jeff Wereszczynski.

Full Summary: No summary paragraph submitted.

Media
  • Jeff Wereszczynski Jeff Wereszczynski
    (image/jpeg)

Probing the function of chromatin remodeling factors with biomolecular simulations

 

Jeff Wereszczynski, Assistant Professor 

Illinois Institute of Technology

 

Abstract:

Eukaryotes package and maintain their genetic code in chromatin fibers. The fundamental unit of chromatin is the nucleosome, a complex of approximately equal mass of protein and DNA molecules.  By altering the physical and biochemical properties of the nucleosome, the cell regulates the structure and stability of chromatin and thus tunes gene expression. 

In this talk, I will discuss efforts by our group to use molecular dynamics simulations in conjunction with data from NMR, SAXS, and Cryo-EM experiments to understand the processes by which chromatin remodeling factors alter the structure and dynamics of single and poly-nucleosomal arrays.  I will focus on the effects of histone variants, post-translational modifications, and linker histones. 

In addition, I will discuss how we can use Bayesian inference to rigorously determine a minimal ensemble of states of flexible biomolecular complexes to describe the results of small angle X-ray scattering experiments from enhanced sampling simulations.   

Additional Information

In Campus Calendar
No
Groups

Georgia Tech Materials Institute

Invited Audience
Faculty/Staff, Public, Graduate students, Undergraduate students
Categories
Arts and Performance, Career/Professional development, Conference/Symposium, Other/Miscellaneous, Seminar/Lecture/Colloquium
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Status
  • Created By: Farlenthia Walker
  • Workflow Status: Draft
  • Created On: Dec 7, 2017 - 8:28am
  • Last Updated: Dec 7, 2017 - 8:28am