Histone Methylation in Development and Diseases

Event Details
  • Date/Time:
    • Thursday May 4, 2017
      11:00 am - 12:00 pm
  • Location: Georgia Tech, EBB 1005
  • Phone: 404-894-3700
  • URL:
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact
No contact information submitted.
Summaries

Summary Sentence: Seminar by Yali Dou from University of Michigan

Full Summary: No summary paragraph submitted.

Yali Dou, Ph.D
Associate Professor
Department of Pathology
Department of Biological Chemistry
University of Michigan


Abstract:
Epigenetics refers to heritable changes that are not encoded in the DNA sequence. It has emerged that histones, the basic building blocks of the hierarchical chromatin structure in eukaryotes, are major carriers of epigenetic information. The evolutionarily conserved covalent modifications such as histone methylation play important roles in chromatin-template based processes including transcrition, replication and DNA damge repair. Mutations in histone methyltransferases are frequently found in human malignancies. Our research focuses on MLL family histone methyltransferases ant their roles in cell fate determination during physiological and maligant proceses. Using combined bioichemistry, genetic and chemical biology approaches, we have uncovered novel mechanisms by which MLL function in cells and establish MLL as a potential therapeutic target in leukemia. 

Additional Information

In Campus Calendar
Yes
Groups

School of Biological Sciences, College of Sciences

Invited Audience
Faculty/Staff, Public, Graduate students, Undergraduate students
Categories
Seminar/Lecture/Colloquium
Keywords
School of Biological Sciences Seminar, Yali Dou, Yuhong Fan
Status
  • Created By: Jasmine Martin
  • Workflow Status: Published
  • Created On: Mar 7, 2017 - 1:29pm
  • Last Updated: May 1, 2017 - 4:36pm