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Signaling through Hydrogen Sulfide
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Hydrogen sulfide is a signaling molecule that is toxic at high levels. We have demonstrated that the H2S-producing enzymes are remarkably promiscuous and that allosteric mechanisms exist to switch their reaction specificity. The sulfide oxidation pathway resides in the mitochondrion, generates reactive sulfur intermediates, and couples to the electron transfer chain, thus making H2S the only known inorganic substrate for ATP synthesis in mammals. Our discovery of novel heme-dependent sulfide oxidation chemistry will be discussed along with a proteomic approach that is revealing persulfidation targets in colon, which is routinely exposed to high sulfide concentrations from sulfate reducing bacteria in the microbiome.
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- Workflow Status:Published
- Created By:Kristen Bailey
- Created:02/20/2017
- Modified By:Fletcher Moore
- Modified:04/13/2017
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