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BME Speaker Seminar with Lukasz Bugaj, Ph.D.*
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*** FACULTY CANDIDATE ***
Lukasz Bugaj, Ph.D.*
Arnold O. Beckman Postdoctoral Fellow,
University of California, San Francisco
Interrogating Cell Signal Perception Using Optogenetics
ABSTRACT
Despite decades of cell signaling studies, we have a limited understanding of the cell signaling code: how can cells make diverse and complex decisions using only a small set of intracellular signaling pathways? An intriguing hypothesis is that cells can decode the strength, dynamics, or combinations of intracellular signals. Optogenetic – or light activatible – tools now enable us to test this hypothesis through precise and tunable control over signaling inputs in living cells. These tools allow us to reverse-engineer the cell, giving fundamental insight into both 1) the cellular machinery and 2) the cell’s ability to process and interpret its dynamic environment. In this talk, I will first describe the engineering of optogenetic proteins for cell signaling, as well as their high-throughput implementation. I will then show how these approaches are revealing principles by which signaling dynamics govern cell fate decisions from neurogenesis to cancer cell proliferation.
Host: Edward Botchwey, Ph.D.
Thursday, February 16
10:30 a.m.
McIntire Room 3115,
Whitaker Bldg.
Videoconference:
Emory: HSRB E182
Georgia Tech: TEP 104
Status
- Workflow Status:Published
- Created By:Walter Rich
- Created:02/09/2017
- Modified By:Fletcher Moore
- Modified:04/13/2017
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