Integrated Cancer Research Center Seminar

Event Details
  • Date/Time:
    • Tuesday October 4, 2016
      4:00 pm - 5:00 pm
  • Location: Petit Institute Biotechnology Building, Room 1128
  • Phone: (404) 894-6228
  • URL: http://petitinstitute.gatech.edu/
  • Email:
  • Fee(s):
    N/A
  • Extras:
Contact

John McDonald, Ph.D. - faculty host

Summaries

Summary Sentence: "Evolutionary Genomics of Prostate Cancer in African Men" - Joseph Lachance, Ph.D - Georgia Tech

Full Summary: No summary paragraph submitted.

Media
  • Integrated Cancer Research Center Integrated Cancer Research Center
    (image/jpeg)

"Evolutionary Genomics of Prostate Cancer in African Men"

Joseph Lachance, Ph.D.
Assistant Professor
School of Biological Sciences
Georgia Tech

 

To determine why African men are more likely to suffer from prostate cancer (CaP), we integrated GWAS results and scans of selection with allele frequency data from 64 global populations.  Despite substantial overlap in genetic risk scores across populations, we find that predicted CaP risk is highest in West Africans and that a small number of loci drive these differences in risk.  There is a strong concordance between genetic risk scores and clinical estimates of CaP mortality.  Although most CaP-associated loci are evolving neutrally, we find multiple instances where alleles have hitchhiked to high frequencies with linked locally adaptive alleles.

Related Links

Additional Information

In Campus Calendar
No
Groups

Parker H. Petit Institute for Bioengineering and Bioscience (IBB)

Invited Audience
Undergraduate students, Faculty/Staff, Graduate students
Categories
Seminar/Lecture/Colloquium
Keywords
go-icrc-events, go_genomics, IBB, ICRC Seminar
Status
  • Created By: Floyd Wood
  • Workflow Status: Draft
  • Created On: Sep 2, 2016 - 9:08am
  • Last Updated: Apr 13, 2017 - 5:14pm