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Dynamics and Regulation of Sec-Facilitated Protein Translocation and Integral Membrane Protein Insertion

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School of Physics Soft Condensed Matter and Biophysics Series: Professor Tom Miller, Caltech

The Sec translocon is a central component of cellular pathways for protein translocation and membrane integration.  Using both atomistic and coarse-grained molecular simulations, we investigate the conformational landscape of the translocon and explore the role of peptide substrates in the regulation of the translocation and integration pathways.   Implications of these results for the regulation of Sec-mediated pathways for protein translocation and membrane integration are discussed.

Status

  • Workflow Status:Published
  • Created By:Alison Morain
  • Created:10/03/2013
  • Modified By:Fletcher Moore
  • Modified:10/07/2016

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